{{Rsnum
|rsid=2854116
|Gene=APOC3
|Chromosome=11
|position=116829453
|Orientation=minus
|GMAF=0.494
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=APOC3
}}{{PharmGKB
|RSID=rs2854116
|Name_s=APOC3: -455 T>C
|Gene_s=APOA4, APOC3
|Feature=Intron, Intron
|Evidence=PubMed ID:15809899; PubMed ID:16417409; PubMed ID:17700364
|Annotation=This promoter variant is associated with hyperlipidemia (elevated triglyceride levels) for HIV-infected individuals treated with ritonavir.
|Drugs=ritonavir
|Drug Classes=
|Diseases=HIV; HIV Infections; Hyperlipidemias
|Curation Level=Curated
|PharmGKB Accession ID=PA162359983
}}

{{PMID Auto
|PMID=20335584
|Title=Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease
|OA=1
}}

{{omim
|id=613387
|rsnum=2854116
}}

{{PMID Auto
|PMID=22105854
|Title=A variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
|OA=1
}}

{{PMID Auto
|PMID=22141340
|Title=Genetic variation in PNPLA3 but not APOC3 influences liver fat in NAFLD
}}

{{PMID Auto
|PMID=18096054
|Title=Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample.
|OA=1
}}

{{PMID Auto
|PMID=18513389
|Title=New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
|OA=1
}}

{{PMID Auto
|PMID=19014573
|Title=Application of two machine learning algorithms to genetic association studies in the presence of covariates.
|OA=1
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19057464
|Title=Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study.
|OA=1
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19263529
|Title=Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
|OA=1
}}

{{PMID Auto
|PMID=21274868
|Title=Dissociation between APOC3 variants, hepatic triglyceride content and insulin resistance.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2854116
|overall_frequency_n=53
|overall_frequency_d=112
|overall_frequency=0.473214
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=40
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22775001
|Title=Polymorphisms in Fas gene is associated with HIV-related lipoatrophy in Thai patients
|OA=1
}}

{{PMID Auto
|PMID=22761283
|Title=Multigene interactions and the prediction of depression in the Wisconsin Longitudinal Study.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}