{{Rsnum
|rsid=2854746
|Gene=IGFBP3
|Chromosome=7
|position=45921046
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=G
|GMAF=0.4826
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=IGFBP3
}}{{PMID Auto
|PMID=19240240
|Title=IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women
|OA=1
}}
{{PMID Auto
|PMID=19551864
|Title=Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease
|OA=1
}}

{{omim
|desc=INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 3; IGFBP3
|id=146732
|rsnum=2854746
}}
{{PMID Auto
|PMID=19784788
|Title=Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk
}}
{{PMID Auto
|PMID=19858071
|Title=Common Genetic Variation in IGF1, IGFBP1, and IGFBP3 and Ovarian Cancer Risk
|OA=1
}}
{{PMID Auto
|PMID=20484221
|Title=A Comprehensive Analysis of Common IGF1, IGFBP1 and IGFBP3 Genetic Variation with Prospective IGF-I and IGFBP-3 Blood Levels and Prostate Cancer Risk Among Caucasians
|OA=1
}}

{{PMID Auto
|PMID=21562710
|Title=Genotypes and phenotypes of IGF-I and IGFBP-3 in breast tumors among Chinese women
}}

{{PMID|17300730|OA=1
}} Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study.

{{PMID|17566087}} Genetic determinants of circulating insulin-like growth factor (IGF)-I, IGF binding protein (BP)-1, and IGFBP-3 levels in a multiethnic population.

{{PMID|18031946}} Polymorphisms in the insulin like growth factor 1 and IGF binding protein 3 genes and risk of colorectal cancer.

{{PMID|18398040|OA=1
}} Transcription factor 7-like 2 polymorphism and colon cancer.

{{PMID|18596909|OA=1
}} IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3).

{{PMID|18992263|OA=1
}} Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.

{{PMID|19938081|OA=1
}} Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.

{{PMID|22354904}} Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: the Multiethnic Cohort study.

{{GET Evidence
|gene=IGFBP3
|aa_change=Ala32Gly
|aa_change_short=A32G
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2854746
|overall_frequency_n=417
|overall_frequency_d=1606
|overall_frequency=0.259651
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|nblosum100=1
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}