{{Rsnum
|rsid=2872507
|Chromosome=17
|position=39884510
|Orientation=plus
|GMAF=0.3627
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 22.1 | 50.4 | 27.4
| HCB | 10.2 | 45.3 | 44.5
| JPT | 8.0 | 40.7 | 51.3
| YRI | 3.4 | 34.0 | 62.6
| ASW | 17.5 | 36.8 | 45.6
| CHB | 10.2 | 45.3 | 44.5
| CHD | 6.4 | 40.4 | 53.2
| GIH | 11.9 | 45.5 | 42.6
| LWK | 6.4 | 30.9 | 62.7
| MEX | 17.2 | 43.1 | 39.7
| MKK | 2.6 | 27.6 | 69.9
| TSI | 19.6 | 52.0 | 28.4
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=18587394
|Trait=Crohn's disease
|Title=Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease
|RiskAllele=A
|Pval=5.0000000000000001E-9
|OR=1.12
|ORtxt=[NR]
|OA=1
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 22; IBD22
|id=612380
|rsnum=2872507
}}

{{PMID Auto GWAS
|PMID=20453842
|Trait=Rheumatoid arthritis
|Title=Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lock
|RiskAllele=A
|Pval=9E-7
|OR=1.10
|ORtxt=[NR]
}}
{{PMID Auto
|PMID=21072187
|Title=Evidence for Significant Overlap between Common Risk Variants for Crohn's Disease and Ankylosing Spondylitis
|OA=1
}}

{{PMID Auto GWAS
|PMID=21297633
|Trait=None
|Title=Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
|RiskAllele=A
|Pval=5E-11
|OR=1.1500
|ORtxt=[1.10-1.19]
|OA=1
}}

{{PMID Auto
|PMID=21752155
|Title=Genetic susceptibility to inflammation and colonic transit in lower functional gastrointestinal disorders: preliminary analysis
|OA=1
}}

{{PMID Auto GWAS
|PMID=21829393
|Trait=None
|Title=Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|RiskAllele=A
|Pval=0.000002
|OR=1.1000
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto
|PMID=22365150
|Title=Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12
|OA=1
}}

{{PMID|19068216|OA=1
}} Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.

{{PMID|19264973|OA=1
}} Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.

{{PMID|19474294|OA=1
}} Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

{{PMID|19732864|OA=1
}} Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.

{{PMID|20369022|OA=1
}} Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.

{{PMID|21304977|OA=1
}} An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2872507
|overall_frequency_n=43
|overall_frequency_d=126
|overall_frequency=0.34127
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=34
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=21102463
  |Trait=Crohn's disease
  |Title=Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
  |RiskAllele=A
  |Pval=2E-9
  |OR=1.14
  |ORtxt=[1.09-1.19]
  |OA=1
}}

{{PMID Auto
|PMID=22694930
|Title=Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases.
|OA=1
}}

{{PMID Auto
|PMID=22986918
|Title=Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}