{{Rsnum
|rsid=28756986
|Gene=MLH3
|Chromosome=14
|position=75047786
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=C
|GMAF=0.007805
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=MLH3
}}{{omim
|desc=COLON CANCER, HEREDITARY NONPOLYPOSIS, TYPE 7
|id=604395
|rsnum=28756986
|variant=0004
}}
{{ neighbor
| rsid = 28937871
| distance = 374
}}

{{ClinVar
|rsid=28756986
|Reversed=1
|FwdREF=G
|FwdALT=C
|REF=C
|ALT=G
|RSPOS=75514489
|CHROM=14
|GMAF=0.0078
|dbSNPBuildID=125
|SSR=0
|SAO=1
|VP=0x05006000000004011e110100
|GENEINFO=MLH3:27030
|GENE_NAME=MLH3
|GENE_ID=27030
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000014.8:g.75514489C>G
|CLNORIGIN=1
|Tags=RV;PM;VLD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;LSD;OM
|CAF=0.9922; 0.007805
|CLNACC=RCV000005899.1
|CLNDBN=Reclassified - variant of unknown significance
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=604395.0004
|COMMON=1
|Disease=Reclassified - variant of unknown significance
}}

{{GET Evidence
|gene=MLH3
|aa_change=Glu624Gln
|aa_change_short=E624Q
|impact=benign
|qualified_impact=Low clinical importance, Uncertain benign
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs28756986
|overall_frequency_n=88
|overall_frequency_d=10758
|overall_frequency=0.00817996
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=3
|n_articles_annotated=3
|qualityscore_in_silico=0
|qualitycomment_in_silico=Y
|qualityscore_in_vitro=2
|qualitycomment_in_vitro=Y
|qualityscore_case_control=1
|qualitycomment_case_control=Y
|qualityscore_familial=1
|qualitycomment_familial=Y
|in_omim=Y
|pph2_score=0.711
|nblosum100=-2
|autoscore=3
|webscore=N
|n_web_uneval=9
|variant_evidence=0
|clinical_importance=0
|summary_short=Probably benign, follow-up studies have failed to support any link with colorectal cancer and the protein function is identical to wildtype.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}