{{Rsnum
|rsid=28756990
|Gene=MLH3
|Chromosome=14
|position=75047435
|Orientation=plus
|GMAF=0.01653
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=MLH3
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 96.4 | 3.6 | 0.0
| HCB | 94.7 | 5.3 | 0.0
| JPT | 92.7 | 7.3 | 0.0
| YRI | 89.0 | 10.3 | 0.7
| ASW | 89.5 | 7.0 | 3.5
| CHB | 94.7 | 5.3 | 0.0
| CHD | 92.7 | 7.3 | 0.0
| GIH | 90.0 | 10.0 | 0.0
| LWK | 81.7 | 17.4 | 0.9
| MEX | 91.2 | 8.8 | 0.0
| MKK | 87.0 | 13.0 | 0.0
| TSI | 97.0 | 3.0 | 0.0
| HapMapRevision=28
}}{{omim
|id=604395
|rsnum=28756990
|variant=0007
}}

{{ClinVar
|rsid=28756990
|Reversed=1
|FwdREF=G
|FwdALT=A,T
|REF=C
|ALT=A,T
|RSPOS=75514138
|CHROM=14
|GMAF=0.0169
|dbSNPBuildID=125
|SSR=0
|SAO=1
|VP=0x050160000000150517110100
|GENEINFO=MLH3:27030
|GENE_NAME=MLH3
|GENE_ID=27030
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000014.8:g.75514138C>A
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=604395.0007
|CLNSIG=5
|CLNCUI=C0476089; C1858380
|CLNDBN=Endometrial carcinoma; Hereditary nonpolyposis colorectal cancer type 7
|Disease=Endometrial carcinoma; Hereditary nonpolyposis colorectal cancer type 7
|CLNACC=RCV000005900.1; RCV000005901.1
|Tags=RV;PM;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.9835; 0.01653; .
|CLNDSDB=MedGen:OMIM:SNOMED_CT; MedGen:OMIM:Orphanet
|CLNDSDBID=C0476089:608089:254878006; C1858380:614385:144
|COMMON=1
}}

{{GET Evidence
|gene=MLH3
|aa_change=Val741Phe
|aa_change_short=V741F
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=other
|quality_scores=Array
|dbsnp_id=rs28756990
|overall_frequency_n=246
|overall_frequency_d=10758
|overall_frequency=0.0228667
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=2
|n_articles_annotated=2
|qualityscore_case_control=0
|qualitycomment_case_control=Y
|qualityscore_familial=2
|qualitycomment_familial=Y
|in_omim=Y
|pph2_score=0.024
|nblosum100=3
|autoscore=2
|webscore=N
|n_web_uneval=6
|summary_short=This variant is implicated in various familial cancers.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}