{{Rsnum
|rsid=28777
|Gene=SLC45A2
|Chromosome=5
|position=33958854
|Orientation=plus
|GMAF=0.4894
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=SLC45A2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 95.6 | 4.4 | 0.0
| HCB | 0.0 | 22.1 | 77.9
| JPT | 3.6 | 27.0 | 69.4
| YRI | 2.8 | 25.0 | 72.2
| ASW | 8.8 | 52.6 | 38.6
| CHB | 0.0 | 22.1 | 77.9
| CHD | 0.9 | 24.1 | 75.0
| GIH | 6.9 | 37.6 | 55.4
| LWK | 1.8 | 31.8 | 66.4
| MEX | 23.2 | 42.9 | 33.9
| MKK | 9.0 | 44.2 | 46.8
| TSI | 96.0 | 3.0 | 1.0
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs28777
|PubMedID=18483556
|Condition=Black vs. red hair color
|Gene=MATP
|Risk Allele=C
|pValue=9.00E-014
|OR=0.46
|95CI=0.34-0.58) decrease in hair color scor
|OA=1
}}

{{PharmGKB
|RSID=rs28777
|Name_s=
|Gene_s=SLC45A2
|Feature=
|Evidence=PubMed ID:18483556; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation (Initial Sample Size: 2,287 women; Replication Sample Size: up to 8,465 individuals; Risk/trait Allele: rs28777-C). This variant is associated with Black vs. blond hair color.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356370
}}

{{PMID Auto
|PMID=19710684
|Title=Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma
|OA=1
}}

{{PharmGKB
|RSID=rs28777
|Name_s=
|Gene_s=SLC45A2
|Feature=
|Evidence=PubMed ID:18483556; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation (Initial Sample Size: 2,287 women; Replication Sample Size: up to 8,465 individuals; Risk/trait Allele: rs28777-C). This variant is associated with Black vs. red hair color.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356371
}}

{{PMID Auto
|PMID=19340012
|Title=Genome-wide association study of tanning phenotype in a population of European ancestry.
|OA=1
}}

{{PMID Auto
|PMID=21253569
|Title=Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs28777
|overall_frequency_n=58
|overall_frequency_d=126
|overall_frequency=0.460317
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=50
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23543094
|Title=Testing for associations between loci and environmental gradients using latent factor mixed models.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}