{{Rsnum
|rsid=2877716
|Gene=ADCY5
|Chromosome=3
|position=123375604
|Orientation=plus
|GMAF=0.1814
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ADCY5
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 55.8 | 38.9 | 5.3
| HCB | 98.5 | 1.5 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 51.0 | 43.4 | 5.5
| ASW | 59.6 | 28.1 | 12.3
| CHB | 98.5 | 1.5 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 58.6 | 36.4 | 5.1
| LWK | 50.5 | 41.3 | 8.3
| MEX | 49.1 | 33.3 | 17.5
| MKK | 71.2 | 26.3 | 2.6
| TSI | 69.3 | 26.7 | 4.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=20081857
|Trait=Two-hour glucose challenge
|Title=Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
|RiskAllele=C
|Pval=7E-16
|OR=0.09
|ORtxt=[0.07-0.11] mmol/L increase
|OA=1
}}

{{PharmGKB
|RSID=rs2877716
|Name_s=
|Gene_s=ADCY5
|Feature=
|Evidence=PubMed ID:20081857
|Annotation=Risk or phenotype-associated allele: C . Phenotype: In a meta-analysis of nine genome-wide association studies (n = 15,234 nondiabetic individuals) and a follow-up of 29 independent loci (n = 6,958-30,620), this SNP was found to be associated with 2-h glucose level (a clinical measure of glucose tolerance). Effect (s.e.m.) = 0.09(0.01) mmol/l per C allele. Study size/population/ethnicity: 15,234 plus 6,958-30,620 nondiabetic individuals of European descent. Significance metric(s): p = 4.19 x 10(-16). Type of association: CO;GN.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA165281981
}}

{{omim
|id=137241
|rsnum=2877716
}}

{{omim
|id=613460
|rsnum=2877716
}}

{{PMID Auto
|PMID=21278902
|Title=Genetic risk profiling for prediction of type 2 diabetes.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2877716
|overall_frequency_n=95
|overall_frequency_d=122
|overall_frequency=0.778689
|n_genomes=49
|n_genomes_annotated=0
|n_haplomes=78
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}