{{Rsnum
|rsid=2881766
|Gene=ESR1
|Chromosome=6
|position=151797984
|Orientation=plus
|GMAF=0.4118
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=ESR1
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 4.4 | 31.0 | 64.6
| HCB | 20.6 | 47.8 | 31.6
| JPT | 17.9 | 54.5 | 27.7
| YRI | 49.3 | 42.5 | 8.2
| ASW | 35.1 | 50.9 | 14.0
| CHB | 20.6 | 47.8 | 31.6
| CHD | 15.6 | 46.8 | 37.6
| GIH | 5.9 | 52.5 | 41.6
| LWK | 58.2 | 33.6 | 8.2
| MEX | 20.7 | 46.6 | 32.8
| MKK | 28.4 | 51.0 | 20.6
| TSI | 5.9 | 20.6 | 73.5
| HapMapRevision=28
}}
[[rs2881766]] is a SNP in the promoter region of the estrogen receptor alpha [[ESR1]] gene.

Carriers of [[rs2881766]](T) alleles are at somewhat (slightly) higher risk for pregnancy-induced [[hypertension]].{{PMID|18360040}}

{{PMID Auto
|PMID=18408366
|Title=Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome.
|OA=1
}}

{{PMID Auto
|PMID=18636124
|Title=Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}