{{Rsnum
|rsid=288326
|Gene=FRZB
|Chromosome=2
|position=182838608
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.05464
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=FRZB
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 3.5 | 19.5 | 77.0
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.7 | 99.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 1.0 | 3.0 | 96.0
| LWK | 0.0 | 0.9 | 99.1
| MEX | 0.0 | 10.3 | 89.7
| MKK | 0.0 | 3.2 | 96.8
| TSI | 0.0 | 25.5 | 74.5
| HapMapRevision=28
}}
{{omim
|desc=OSTEOARTHRITIS OF HIP, FEMALE-SPECIFIC, SUSCEPTIBILITY TO
|id=605083
|rsnum=288326
|variant=0002
}}

{{PMID|19479880}} Meta-analysis of 14 studies did not support a significant association between [[rs288326]] and osteoarthritis.

{{PMID Auto
|PMID=22095095
|Title=Variant alleles of the WNT antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis
}}

{{ClinVar
|rsid=288326
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=183703336
|CHROM=2
|GMAF=0.0549
|dbSNPBuildID=79
|SSR=0
|SAO=1
|VP=0x050168000000150517110100
|GENEINFO=FRZB:2487
|GENE_NAME=FRZB
|GENE_ID=2487
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000002.11:g.183703336G>A
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=605083.0002
|CLNSIG=255
|CLNCUI=C0029408
|CLNDBN=Osteoarthritis susceptibility 1
|Disease=Osteoarthritis susceptibility 1
|CLNACC=RCV000005531.1
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.9454; 0.05464
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C0029408:165720
|COMMON=1
}}

{{PMID|15210948|OA=1
}} Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

{{PMID|17237116|OA=1
}} Further evidence of the role of frizzled-related protein gene polymorphisms in osteoarthritis.

{{PMID|19961594|OA=1
}} Power of multifactor dimensionality reduction and penalized logistic regression for detecting gene-gene interaction in a case-control study.

{{PMID|20043861|OA=1
}} No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families.

{{PMID|22544526|OA=1
}} Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis.

{{GET Evidence
|gene=FRZB
|aa_change=Arg200Trp
|aa_change_short=R200W
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs288326
|overall_frequency_n=924
|overall_frequency_d=10758
|overall_frequency=0.0858896
|n_genomes=6
|n_genomes_annotated=0
|n_haplomes=6
|n_articles=0
|n_articles_annotated=0
|in_omim=Y
|pph2_score=0.999
|nblosum100=7
|autoscore=3
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}