{{Rsnum
|rsid = 28897672
|Gene = BRCA1
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=G
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Chromosome=17
|position=43106487
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=BRCA1
}}[[rs28897672]] is a SNP causing an amino acid change in the breast cancer 1 [[BRCA1]] gene at amino position 61. The more common [[rs28897672]](T) allele encodes Cys, while the rare [[rs28897672]](G) allele encodes Gly; this variation is also known as Cys61Gly or C61G.

A study of 66 Polish families affected with [[breast cancer]] or [[ovarian cancer]], often diagnosed at a relatively young age (< 50 years old), screened for BRCA1 mutations by sequencing. The C61G mutation accounted for 20% of the identified mutations in this group of families.{{PMID|10788334|OA=1
}}

* See also [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=113705&a=113705_AllelicVariant0002 Omim 113705.0002]

{{omim
|id=113705
|rsnum=28897672
|variant=0002
}}

{{ClinVar
|rsid=28897672
|Reversed=1
|FwdREF=T
|FwdALT=A,C,G
|REF=A
|ALT=C,G,T
|RSPOS=41258504
|CHROM=17
|dbSNPBuildID=125
|SSR=0
|SAO=1
|VP=0x050160000000000502110104
|GENEINFO=BRCA1:672
|GENE_NAME=BRCA1
|GENE_ID=672
|WGT=0
|VC=SNV
|CLNALLE=1; 2; 3
|CLNHGVS=NC_000017.10:g.41258504A>C; NC_000017.10:g.41258504A>G; NC_000017.10:g.41258504A>T
|CLNORIGIN=1
|CLNSRCID=
113705.0002
|CLNSIG=255
|CLNCUI=
|CLNACC=
RCV000019229.3; RCV000047597.2; RCV000047596.2; RCV000047595.2
|Tags=RV;PM;SLO;HD;GNO;OTHERKG;LSD;OM;NOV
|CLNDBN=Breast-ovarian cancer, familial 1; Familial cancer of breast
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet; GeneReviews:MedGen:OMIM:SNOMED_CT
|CLNDSDBID=NBK1247:C2676676:604370:145; NBK1247:C0346153:114480:254843006
|CLNSRC=OMIM Allelic Variant
|Disease=Breast-ovarian cancer; Familial cancer of breast
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}