{{Rsnum
|rsid=28897696
|Gene=BRCA1
|Chromosome=17
|position=43063903
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=A
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=BRCA1
}}[[rs28897696]], also known as A1708E, is a SNP in the [[BRCA1]] gene. The far more common (C) allele encodes the amino acid alanine (A), while the very rare (A) allele encodes glutamic acid (E). 

An analysis of sequence variants of unknown clinical significance in the [[BRCA1]] and [[BRCA2]] genes concluded that this SNP was among the top 10 (over both genes) likely to lead to [[breast cancer]], with a calculated odds of over 1,000:1 against this just being a spurious association. Although the clinical importance has not been proven, this may still be of use for genetic counseling.{{PMID|17924331|OA=1
}}

{{ population diversity
| geno1 = (A;C)
| geno2 = (C;C)
| geno3 = 
| CEU | 0 | 0 | 0
| CHB | 0 | 0 | 0
| JPT | 1.2 | 98.8 | 0
| YRI | 0 | 0 | 0
}}

{{ClinVar
|rsid=28897696
|Reversed=1
|FwdREF=C
|FwdALT=A,T
|REF=G
|ALT=A,T
|RSPOS=41215920
|CHROM=17
|dbSNPBuildID=125
|SSR=0
|SAO=0
|VP=0x050360000000040503100100
|GENEINFO=BRCA1:672
|GENE_NAME=BRCA1
|GENE_ID=672
|WGT=0
|VC=SNV
|CLNALLE=2
|CLNHGVS=NC_000017.10:g.41215920G>T
|CLNSIG=5
|Tags=RV;PM;S3D;SLO;VLD;HD;GNO;OTHERKG;PH3;LSD
|CLNACC=RCV000048802.2; RCV000077599.2
|CLNDBN=Familial cancer of breast; Breast-ovarian cancer, familial 1
|CLNDSDB=GeneReviews:MedGen:OMIM:SNOMED_CT; GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1247:C0346153:114480:254843006; NBK1247:C2676676:604370:145
|Disease=Familial cancer of breast; Breast-ovarian cancer
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}