{{Rsnum
|rsid = 28931568
|Gene = SERPINA1
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=A
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Chromosome=14
|position=94382966
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=SERPINA1
}}[[rs28931568]] is a SNP representing an amino acid change in the [[SERPINA1]] gene, which encodes alpha-1-antitrypsin (AAT).

Carriers of two [[rs28931568]](A) alleles, i.e. homozygotes, are at high risk for [[emphysema]] based on the finding of this variant in an affected African-American family.{{PMID|269618}}

{{omim
|desc=PI M(MINERAL SPRINGS)
|id=107400
|rsnum=28931568
|variant=0015
}}
{{ neighbor
| rsid = 28931572
| distance = 75
}}
{{ neighbor
| rsid = 28931569
| distance = 78
}}

{{ClinVar
|rsid=28931568
|Reversed=1
|FwdREF=G
|FwdALT=A
|REF=C
|ALT=T
|RSPOS=94849303
|CHROM=14
|dbSNPBuildID=137
|SSR=0
|SAO=0
|VP=0x050260000000000002110100
|GENEINFO=SERPINA1:5265
|GENE_NAME=SERPINA1
|GENE_ID=5265
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000014.8:g.94849303C>T
|CLNSIG=255
|Tags=RV;PM;S3D;OTHERKG;LSD;OM
|CLNACC=RCV000019566.1
|CLNDBN=PI M(MINERAL SPRINGS)
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=107400.0015
|Disease=PI M(MINERAL SPRINGS)
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}