{{Rsnum
|rsid = 28933386
|Chromosome=12
|Orientation=plus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|position=112477719
|Gene=PTPN11
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=PTPN11
}}{{omim
|desc=NOONAN SYNDROME 1
|id=176876
|rsnum=28933386
|variant=0003
}}

{{ClinVar
|rsid=28933386
|Reversed=0
|FwdREF=A
|FwdALT=G
|REF=A
|ALT=G
|RSPOS=112915523
|CHROM=12
|dbSNPBuildID=131
|SSR=1
|SAO=1
|VP=0x050368000000000002110100
|GENEINFO=PTPN11:5781
|GENE_NAME=PTPN11
|GENE_ID=5781
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000012.11:g.112915523A>G
|CLNSRC=GeneReviews; OMIM Allelic Variant
|CLNORIGIN=0
|CLNSRCID=NBK1124; 176876.0003
|CLNSIG=5
|CLNCUI=C0041409; C0041409
|CLNDBN=Noonan syndrome 1; Rasopathy; Noonan's syndrome; not provided
|Disease=Noonan syndrome 1; Rasopathy; Noonan's syndrome; not provided
|CLNACC=RCV000014254.26; RCV000033516.3; RCV000037667.1; RCV000077863.1
|Tags=PM;PMC;S3D;SLO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet; MedGen; GeneReviews:MedGen:OMIM:SNOMED_CT
|CLNDSDBID=NBK1124:C0041409:163950:648; CN166718; NBK1124:C0028326:163950:205824006
}}

{{PMID Auto
|PMID=11704759
|Title=Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome.
}}

{{PMID Auto
|PMID=11992261
|Title=PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity.
|OA=1
}}

{{PMID Auto
|PMID=12161469
|Title=PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome.
}}

{{PMID Auto
|PMID=15723289
|Title=Genotypic and phenotypic characterization of Noonan syndrome: new data and review of the literature.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}