{{Rsnum
|rsid=28933390
|Gene=BCHE
|Chromosome=3
|position=165829781
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=T
|GMAF=0.003673
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=BCHE
}}(T;T) abolishes catalytic activity in [[BCHE]] according to [http://sites.google.com/site/annerwright/snps annerwright]

{{omim
|desc=BCHE, FLUORIDE 2
|id=177400
|rsnum=28933390
|variant=0004
}}
{{ neighbor
| rsid = 28933389
| distance = 441
}}

{{PharmGKB
|RSID=rs28933390
|Name_s=BCHE: Fluoride resistant II, BCHE:Gly390Val
|Gene_s=BCHE
|Feature=
|Evidence=PubMed ID:1415224
|Annotation=This variant is associated with prolonged apnea is response to succinyldicholine (also known as succinylcholine).
|Drugs=dibucaine; succinylcholine
|Drug Classes=
|Diseases=Apnea
|Curation Level=Curated
|PharmGKB Accession ID=PA162360662
}}

{{ClinVar
|rsid=28933390
|Reversed=1
|FwdREF=G
|FwdALT=T
|REF=C
|ALT=A
|RSPOS=165547569
|CHROM=3
|GMAF=0.0037
|dbSNPBuildID=129
|SSR=0
|SAO=1
|VP=0x05026000000004041e110100
|GENEINFO=BCHE:590
|GENE_NAME=BCHE
|GENE_ID=590
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000003.11:g.165547569C>A
|CLNORIGIN=1
|CLNSIG=5
|Tags=RV;PM;S3D;VLD;HD;KGPhase1;KGPilot123;KGPROD;OTHERKG;LSD;OM
|CAF=0.9963; 0.003673
|CLNACC=RCV000014116.23; RCV000014117.16; RCV000014118.23; RCV000014119.23
|CLNDBN=Bche, fluoride 2; BCHE, FLUORIDE-RESISTANT II; CHE*390V; BCHE*390V
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=177400.0004
|COMMON=1
|Disease=Bche; BCHE; CHE*390V; BCHE*390V
}}

{{GET Evidence
|gene=BCHE
|aa_change=Gly418Val
|aa_change_short=G418V
|impact=pharmacogenetic
|qualified_impact=High clinical importance,  pharmacogenetic
|inheritance=recessive
|quality_scores=Array
|dbsnp_id=rs28933390
|overall_frequency_n=39
|overall_frequency_d=10758
|overall_frequency=0.00362521
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=1
|n_articles_annotated=1
|qualityscore_in_silico=3
|qualitycomment_in_silico=Y
|qualityscore_case_control=5
|qualitycomment_case_control=Y
|qualityscore_severity=3
|qualitycomment_severity=Y
|qualityscore_treatability=5
|qualitycomment_treatability=Y
|pph2_score=0.941
|nblosum100=8
|autoscore=3
|n_web_uneval=9
|variant_evidence=2
|clinical_importance=2
|summary_short=This is the "flu-2" variant of BCHE and can cause prolonged post-succinylcholine apnea (an adverse side-effect of prolonged response to anesthesia) when homozygous or compound heterozygous with other deleterious BCHE variants.
}}

[[Pseudocholinesterase Deficiency]]

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}