{{Rsnum
|rsid = 28933397
|Gene = RYR1
|geno1 = (C;C)
|geno2 = (C;T)
|geno3 = (T;T)
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|Chromosome=19
|position=38500654
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=RYR1
}}{{omim
|desc=MALIGNANT HYPERTHERMIA, SUSCEPTIBILITY TO, 1
|id=180901
|rsnum=28933397
|variant=0008
}}
{{ neighbor
| rsid = 28933396
| distance = 657
}}

{{PharmGKB
|RSID=rs28933397
|Name_s=ARG2458CYS;7372CT
|Gene_s=RYR1
|Feature=
|Evidence=PubMed ID:10051009; PubMed ID:11668625
|Annotation=Malignant Hyperthermia Susceptibility.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161145112
}}

{{ClinVar
|rsid=28933397
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=38991294
|CHROM=19
|dbSNPBuildID=133
|SSR=0
|SAO=1
|VP=0x050168000000000002110100
|GENEINFO=RYR1:6261
|GENE_NAME=RYR1
|GENE_ID=6261
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000019.9:g.38991294C>T
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=0
|CLNSRCID=180901.0008
|CLNSIG=255
|CLNCUI=C0024591
|CLNDBN=Malignant hyperthermia
|Disease=Malignant hyperthermia
|CLNACC=RCV000013838.1
|Tags=PM;PMC;SLO;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1146:C0024591:145600:423
}}

{{PMID Auto
|PMID=16835904
|Title=Frequency and localization of mutations in the 106 exons of the RYR1 gene in 50 individuals with malignant hyperthermia.
}}

{{PMID Auto
|PMID=16958617
|Title=Malignant hyperthermia mutation sites in the Leu2442-Pro2477 (DP4) region of RyR1 (ryanodine receptor 1) are clustered in a structurally and functionally definable area.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}