{{Rsnum
|rsid=28934578
|Gene=TP53
|Chromosome=17
|position=7675088
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=A
|Summary=Li-Fraumeni syndrome (an inherited cancer predisposition)
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=TP53
}}[[rs28934578]], also known as 721G>A, R175H and Arg175His, is a SNP in the p53 [[TP53]] tumor suppressor gene.

The rare [[rs28934578]](A) allele is associated with predisposition to cancer in the form of [[Li-Fraumeni syndrome]] 1.

{{omim
|desc=LI-FRAUMENI SYNDROME 1
|id=191170
|rsnum=28934578
|variant=0030
}}
{{ neighbor
| rsid = 28934573
| distance = 847
}}
{{ neighbor
| rsid = 28934874
| distance = 73
}}

{{ClinVar
|rsid=28934578
|Reversed=1
|FwdREF=G
|FwdALT=A
|REF=C
|ALT=T
|RSPOS=7578406
|CHROM=17
|dbSNPBuildID=132
|SSR=0
|SAO=3
|VP=0x050260000000000002110120
|GENEINFO=TP53:7157
|GENE_NAME=TP53
|GENE_ID=7157
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000017.10:g.7578406C>T
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=2
|CLNSRCID=191170.0030
|CLNSIG=5
|CLNCUI=C1835398
|CLNDBN=Li-Fraumeni syndrome 1
|Disease=Li-Fraumeni syndrome 1
|CLNACC=RCV000013173.19
|Tags=RV;PM;S3D;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet:SNOMED_CT
|CLNDSDBID=NBK1311:C1835398:151623:524:428850001
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}