{{Rsnum
|rsid=28936679
|Gene=AANAT
|Chromosome=17
|position=76469731
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.007805
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=AANAT
}}[[rs28936679]], also known as Ala129Thr or A129T (and also G619A), is a SNP in the aralkylamine N-acetyltransferase [[AANAT]] gene. The [[AANAT]] protein plays a unique role in vertebrate biology by controlling rhythmic production of melatonin in the pineal gland. Its activity increases 10- to 100-fold at night, leading to increased production and release of melatonin.

In a 2003 report about Japanese patients with a [[sleep disorder]] known as susceptibility to delayed sleep phase syndrome, patient genotypes had a higher frequency of the [[rs28936679]](A) allele.{{PMID|12736803}}

A later report based on Brazilian (primarily Caucasian) patients including those with delayed sleep phase syndrome found no variation at this SNP.{{PMID|17503170}}


{{omim
|desc=DELAYED SLEEP PHASE SYNDROME, SUSCEPTIBILITY TO
|id=600950
|rsnum=28936679
|variant=0001
}}

{{ClinVar
|rsid=28936679
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=74465813
|CHROM=17
|GMAF=0.0078
|dbSNPBuildID=133
|SSR=0
|SAO=1
|VP=0x050260000000000016110100
|GENEINFO=AANAT:15
|GENE_NAME=AANAT
|GENE_ID=15
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000017.10:g.74465813G>A
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=600950.0001
|CLNSIG=255
|CLNCUI=C0393770
|CLNDBN=Delayed sleep phase syndrome, susceptibility to
|Disease=Delayed sleep phase syndrome
|CLNACC=RCV000009162.1
|Tags=PM;S3D;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9922; 0.007805
|CLNDSDB=MedGen:OMIM:SNOMED_CT
|CLNDSDBID=C0393770:614163:80623000
|COMMON=1
}}

{{on chip | 23andMe v2}}