{{Rsnum
|rsid = 28939676
|Gene = MATN3
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Chromosome=2
|position=20003169
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Status=Merged
|Merged=77245812
|Gene_s=AC079145.4,MATN3
}}{{omim
| id = 602109
| variant = 0003
| desc    = HAND OSTEOARTHRITIS, SUSCEPTIBILITY TO
| rsnum   = 28939676
}}{{GET Evidence
|gene=MATN3
|aa_change=Thr303Met
|aa_change_short=T303M
|impact=pathogenic
|qualified_impact=Moderate clinical importance, Uncertain pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs28939676
|overall_frequency_n=108
|overall_frequency_d=10122
|overall_frequency=0.0106698
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=1
|n_articles_annotated=1
|qualityscore_in_silico=1
|qualitycomment_in_silico=Y
|qualityscore_case_control=1
|qualitycomment_case_control=Y
|qualityscore_familial=2
|qualitycomment_familial=Y
|qualityscore_severity=3
|qualitycomment_severity=Y
|qualityscore_treatability=3
|gene_in_genetests=Y
|in_omim=Y
|pph2_score=1.0
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=2
|autoscore=6
|webscore=N
|n_web_uneval=10
|variant_evidence=1
|clinical_importance=0
|summary_short=An Iceland study implicated this in causing increased osteoarthritis -- in particular, hand osteoarthritis. Because the variant is rare, the statistical significance of observations is weak. The authors estimate that individuals heterozygous for this variant have a 2.1-fold risk for hand osteoarthritis.
}}