{{Rsnum
|rsid = 28940578
|Gene = MEFV
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Chromosome=16
|position=3243405
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=MEFV
}}{{omim
|desc=FAMILIAL MEDITERRANEAN FEVER
|id=608107
|rsnum=28940578
|variant=0002
}}
{{ neighbor
| rsid = 28940579
| distance = 95
}}
{{ neighbor
| rsid = 28940577
| distance = 5
}}

The symptoms of [[familial Mediterranean fever]] are caused by the person's own inflammatory response; it is not an [[infectious disease]]. The condition is more common among [[Turks]], [[Sephardic Jews]], and people of [[Arab]] and [[Armenian]] ancestry.

23andMe tests for SNPs in the [[MEFV]] gene that are associated with a recessive form of [[familial Mediterranean fever]]:
* [[rs28940579]], also known as V726A (risk allele G)
* [[rs28940580]], also known as M680I C>G (risk allele G)
* [[rs28940578]], also known as M694I (risk allele T)
* [[rs3743930]], also known as E148Q (risk allele G)
* [[rs11466023]], also known as P369S (risk allele A)
* [[i4000406]], also known as M694V (risk allele C)
* [[i4000409]], also known as A744S (risk allele A)
* [[i4000403]], also known as F479L (risk allele C)
* [[i4000410]], also known as R761H (risk allele T)
* [[i4000407]], also known as K695R (risk allele C)

{{ClinVar
|rsid=28940578
|Reversed=1
|FwdREF=G
|FwdALT=A
|REF=C
|ALT=T
|RSPOS=3293405
|CHROM=16
|dbSNPBuildID=132
|SSR=0
|SAO=1
|VP=0x050268000000000002110100
|GENEINFO=MEFV:4210
|GENE_NAME=MEFV
|GENE_ID=4210
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000016.9:g.3293405C>T
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=608107.0002; 608107.0018
|CLNSIG=5
|CLNCUI=C0031069; C1851347
|CLNDBN=Familial Mediterranean fever; Familial mediterranean fever, autosomal dominant
|Disease=Familial Mediterranean fever; Familial mediterranean fever
|CLNACC=RCV000002648.1; RCV000002664.1
|Tags=RV;PM;PMC;S3D;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet:SNOMED_CT; MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1227:C0031069:249100:342:12579009; C1851347:134610:342
}}

{{PMID|19784369|OA=1
}} Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis.

{{PMID|17331}} A rapid accurate assay for choline kinase.

{{PMID|10090880|OA=1
}} Mutation and haplotype studies of familial Mediterranean fever reveal new ancestral relationships and evidence for a high carrier frequency with reduced penetrance in the Ashkenazi Jewish population.

{{PMID|10364520|OA=1
}} MEFV-Gene analysis in armenian patients with Familial Mediterranean fever: diagnostic value and unfavorable renal prognosis of the M694V homozygous genotype-genetic and therapeutic implications.

{{PMID|19967574}} A case of familial Mediterranean fever associated with compound heterozygosity for the pyrin variant L110P-E148Q/M680I in Japan.

{{PMID|20041150|OA=1
}} Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels.

{{PMID|20534143|OA=1
}} 1Novel MEFV transcripts in Familial Mediterranean fever patients and controls.

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}