{{Rsnum
|rsid=28940579
|Gene=MEFV
|Chromosome=16
|position=3243310
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.0004591
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=MEFV
}}{{omim
|desc=FAMILIAL MEDITERRANEAN FEVER
|id=608107
|rsnum=28940579
|variant=0003
}}
{{ neighbor
| rsid = 28940578
| distance = 95
}}

The symptoms of [[familial Mediterranean fever]] are caused by the person's own inflammatory response; it is not an [[infectious disease]]. The condition is more common among [[Turks]], [[Sephardic Jews]], and people of [[Arab]] and [[Armenian]] ancestry.

23andMe tests for SNPs in the [[MEFV]] gene that are associated with a recessive form of [[familial Mediterranean fever]]:
* [[rs28940579]], also known as V726A (risk allele G)
* [[rs28940580]], also known as M680I C>G (risk allele G)
* [[rs28940578]], also known as M694I (risk allele T)
* [[rs3743930]], also known as E148Q (risk allele G)
* [[rs11466023]], also known as P369S (risk allele A)
* [[i4000406]], also known as M694V (risk allele C)
* [[i4000409]], also known as A744S (risk allele A)
* [[i4000403]], also known as F479L (risk allele C)
* [[i4000410]], also known as R761H (risk allele T)
* [[i4000407]], also known as K695R (risk allele C)

{{ClinVar
|rsid=28940579
|Reversed=1
|FwdREF=T
|FwdALT=C
|REF=A
|ALT=G
|RSPOS=3293310
|CHROM=16
|GMAF=0.0005
|dbSNPBuildID=129
|SSR=0
|SAO=1
|VP=0x050268000000040116110100
|GENEINFO=MEFV:4210
|GENE_NAME=MEFV
|GENE_ID=4210
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000016.9:g.3293310A>G
|CLNSRC=OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=608107.0003
|CLNSIG=5
|CLNCUI=C0031069
|CLNDBN=Familial Mediterranean fever
|Disease=Familial Mediterranean fever
|CLNACC=RCV000002649.1
|Tags=RV;PM;PMC;S3D;VLD;GNO;KGPhase1;KGPROD;OTHERKG;LSD;OM
|CAF=0.9995; 0.0004591
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet:SNOMED_CT
|CLNDSDBID=NBK1227:C0031069:249100:342:12579009
|COMMON=0
}}

{{PMID Auto
|PMID=19784369
|Title=Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis.
|OA=1
}}

{{PMID Auto
|PMID=12401
|Title=[X-ray assessment of the motor-evacuatory function of the gastrointestinal tract in the diagnosis of the dumping-syndrome].
}}

{{PMID Auto
|PMID=10024914
|Title=Pyrin/marenostrin mutations in familial Mediterranean fever.
}}

{{PMID Auto
|PMID=10737995
|Title=The E148Q mutation in the MEFV gene: is it a disease-causing mutation or a sequence variant?
}}

{{PMID Auto
|PMID=11017802
|Title=Identification of MEFV-independent modifying genetic factors for familial Mediterranean fever.
|OA=1
}}

{{PMID Auto
|PMID=12929299
|Title=Analysis of the three most common MEFV mutations in 412 patients with familial Mediterranean fever.
}}

{{PMID Auto
|PMID=20041150
|Title=Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}