{{Rsnum
|rsid=2894342
|Chromosome=6
|position=33806617
|Orientation=minus
|GMAF=0.2314
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 53.1 | 42.5 | 4.4
| HCB | 65.9 | 31.9 | 2.2
| JPT | 62.8 | 33.6 | 3.5
| YRI | 69.4 | 29.9 | 0.7
| ASW | 82.5 | 17.5 | 0.0
| CHB | 65.9 | 31.9 | 2.2
| CHD | 80.7 | 17.4 | 1.8
| GIH | 52.5 | 41.6 | 5.9
| LWK | 78.2 | 21.8 | 0.0
| MEX | 36.2 | 44.8 | 19.0
| MKK | 73.5 | 24.5 | 1.9
| TSI | 59.8 | 31.4 | 8.8
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2894342
|Name_s=
|Gene_s=MLN
|Feature=
|Evidence=PubMed ID:16538176
|Annotation=Risk or phenotype-associated allele: A allele. Phenotype: The A allele rs2894342, which lies in the promoter of MLN, is associated with carbamazepine (CBZ)-induced maculopapular exanthema (MPE)/ hypersensitivity syndrome (HSS). Study size: 175. Study population/ethnicity: 31 CBZ-induced MPE/HSS cases and 144 CBZ-tolerant controls of Chinese descent. Significance metric(s): p = 0.00342, OR = 2.88. Type of association: GN; PD; TOX; ADR.
|Drugs=carbamazepine
|Drug Classes=
|Diseases=Drug Hypersensitivity; Exanthema; Maculopapular Exanthema
|Curation Level=Curated
|PharmGKB Accession ID=PA165291961
}}

{{PharmGKB
|RSID=rs2894342
|Name_s=
|Gene_s=MLN
|Feature=
|Evidence=PubMed ID:16538176
|Annotation=The A allele of this SNP has been associated with Drug Hypersensitivity in Chinese populations in response to carbamazepine treatment.
|Drugs=carbamazepine
|Drug Classes=
|Diseases=Drug Hypersensitivity
|Curation Level=Curated
|PharmGKB Accession ID=PA162316743
}}

{{PharmGKB
|RSID=rs2894342
|Name_s=
|Gene_s=MLN
|Feature=
|Evidence=PubMed ID:16538176
|Annotation=Risk or phenotype-associated allele: A allele. Phenotype: The A allele rs2894342, which lies in the promoter of MLN, is associated with carbamazepine (CBZ)-induced hypersensitivity syndrome (HSS). Study size: 157. Study population/ethnicity: 13 CBZ-induced HSS cases and 144 CBZ-tolerant controls of Chinese descent. Significance metric(s): p = 0.0000232, OR = 7.11. Type of association: GN; PD; TOX; ADR.
|Drugs=carbamazepine
|Drug Classes=
|Diseases=Drug Hypersensitivity
|Curation Level=Curated
|PharmGKB Accession ID=PA165291962
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2894342
|overall_frequency_n=18
|overall_frequency_d=128
|overall_frequency=0.140625
|n_genomes=15
|n_genomes_annotated=0
|n_haplomes=16
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}
{{on chip | NatGeo2}}