{{Rsnum
|rsid=2903692
|Gene=CLEC16A
|Chromosome=16
|position=11144926
|Orientation=plus
|GMAF=0.3058
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CLEC16A
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 11.5 | 39.8 | 48.7
| HCB | 2.2 | 44.9 | 52.9
| JPT | 2.7 | 26.8 | 70.5
| YRI | 8.2 | 46.9 | 44.9
| ASW | 12.3 | 45.6 | 42.1
| CHB | 2.2 | 44.9 | 52.9
| CHD | 7.5 | 39.3 | 53.3
| GIH | 27.0 | 47.0 | 26.0
| LWK | 12.7 | 42.7 | 44.5
| MEX | 3.4 | 39.7 | 56.9
| MKK | 23.1 | 55.1 | 21.8
| TSI | 20.6 | 53.9 | 25.5
| HapMapRevision=28
}}{{PMID|18940880}} [[rs2292399]] and [[rs2903692]] both significantly associated with [[type 1 diabetes]] odds ratio 1.37 and 1.28. A joint analysis revealed that [[rs3087243]], [[rs2292399]], and [[rs2903692]], but not INS [[rs689]], were significant risk factors for the cooccurrence of AITD

{{GWAS Summary
|SNP=rs2903692
|PubMedID=17632545
|Condition=Type 1 diabetes
|Gene=KIAA0350
|Risk Allele=G
|pValue=7.00E-011
|OR=1.54
|95CI=1.32-1.79
}}

{{PMID Auto
|PMID=19317741
|Title=Autoimmune disease association signals in CIITA and KIAA0350 are not involved in celiac disease susceptibility
}}

{{omim
|desc=DIABETES MELLITUS, INSULIN-DEPENDENT; IDDM
|id=222100
|rsnum=2903692
}}

{{omim
|desc=C-TYPE LECTIN DOMAIN FAMILY 16, MEMBER A; CLEC16A
|id=611303
|rsnum=2903692
}}

{{PharmGKB
|RSID=rs2903692
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17632545; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene (Initial Sample Size: 561 cases, 1,143 controls, 467 trios; Replication Sample Size: 1,333 individuals in 549 families; 390 trios; Risk Allele: rs2903692-G).
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 1
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356672
}}

{{PMID Auto
|PMID=19221398
|Title=Chromosomal region 16p13: further evidence of increased predisposition to immune diseases.
}}

{{PMID Auto
|PMID=19337309
|Title=Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15(-) Crohn's disease patients.
|OA=1
}}

{{PMID Auto
|PMID=20369022
|Title=Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2903692
|overall_frequency_n=40
|overall_frequency_d=128
|overall_frequency=0.3125
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=30
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}