{{Rsnum
|rsid=2910164
|Gene=MIR146A
|Chromosome=5
|position=160485411
|Orientation=plus
|GMAF=0.3815
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=MIR146A
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 6.2 | 34.5 | 59.3
| HCB | 36.5 | 40.1 | 23.4
| JPT | 32.7 | 58.4 | 8.8
| YRI | 21.1 | 48.3 | 30.6
| ASW | 15.8 | 43.9 | 40.4
| CHB | 36.5 | 40.1 | 23.4
| CHD | 38.5 | 45.0 | 16.5
| GIH | 7.9 | 38.6 | 53.5
| LWK | 22.7 | 48.2 | 29.1
| MEX | 6.9 | 51.7 | 41.4
| MKK | 23.1 | 50.0 | 26.9
| TSI | 6.9 | 37.3 | 55.9
| HapMapRevision=28
}}{{PMID|18474871|OA=1
}} (C;C) predisposes to papillary thyroid carcinoma.

{{PMID|18660546}} Among 42 patients with familial [[breast cancer]] and 82 patients with [[ovarian cancer]], those with at least one [[rs2910164]](C) SNP tended to have been diagnosed at an earlier age than those with only (G) alleles. For the breast cancer patients, the difference in median age was between 45 vs 56 (p = 0.029) and for ovarian cancer patients, 45 vs 50, (p = 0.014). 

{{PMID|18711148}} (G;G) males were two-fold more susceptible to hepatocellular carcinoma (OR = 2.016, 95% CI = 1.056-3.848, P = 0.034)

perhaps an [[ambiguous flip]]?

{{snp near feature
| rsid = 2910164
| type = microRNA
| ACC=MI0000477
| ID=hsa-mir-146a
| offset=-10
}}

{{PMID Auto
|PMID=19293314
|Title=A Functional Genetic Variant in microRNA-196a2 Is Associated with Increased Susceptibility of Lung Cancer in Chinese.
}}

{{PMID Auto
|PMID=19514064
|Title=Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population
}}

{{omim
|desc=MICRO RNA 146A; MIRN146A
|id=610566
|rsnum=2910164
}}
{{PMID Auto
|PMID=19847796
|Title=Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases
}}
{{PMID Auto
|PMID=19902466
|Title=A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo
}}

{{PMID Auto
|PMID=20011700
|Title=Analyses of polymorphisms in the inflammasome-associated NLRP3 and miRNA-146A genes in the susceptibility to and tubal pathology of Chlamydia trachomatis infection
}}

{{PMID Auto
|PMID=20488170
|Title=Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy
}}
{{PMID Auto
|PMID=20500689
|Title=The Role of microRNA-146a (miR-146a) and its Target IL-1R-Associated Kinase (IRAK1) in Psoriatic Arthritis Susceptibility
}}
{{PMID Auto
|PMID=20549817
|Title=Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck
|OA=1
}}
{{PMID Auto
|PMID=20640596
|Title=The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis
}}
{{PMID Auto
|PMID=20680470
|Title=A functional varient in microRNA-146a is associated with risk of esophageal squamous cell carcinoma in Chinese Han
}}
{{PMID Auto
|PMID=20842445
|Title=Genetic variation in microRNA genes and prostate cancer risk in North Indian population
}}
{{PMID Auto
|PMID=20848167
|Title=Association Study of Common Genetic Variants in Pre-microRNAs in Patients with Ulcerative Colitis
}}
{{PMID Auto
|PMID=20870441
|Title=A polymorphism in the 3'-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility
}}
{{PMID Auto
|PMID=21073609
|Title=Association Between Common Genetic Variants in Pre-microRNAs and Gastric Cancer Risk in Japanese Population
}}

{{PMID Auto
|PMID=21524676
|Title=Genetic study of two single nucleotide polymorphisms within corresponding microRNAs and susceptibility to tuberculosis in a Chinese Tibetan and Han population
}}

{{PMID Auto
|PMID=21591024
|Title=The rs2910164:G&gt;C SNP in the MIR146A gene is not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
}}

{{PMID Auto
|PMID=21637771
|Title=Effects of Common Polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on Cancer Susceptibility: A Meta-Analysis
|OA=1
}}

{{PMID Auto
|PMID=21744077
|Title=A functional polymorphism in the pre-miR-146a gene is associated with risk and prognosis in adult glioma
|OA=1
}}

{{PMID Auto
|PMID=21807077
|Title=No association of pre-microRNA-146a rs2910164 polymorphism and risk of hepatocellular carcinoma development in Turkish population: A case-control study
}}

{{PMID Auto
|PMID=21861697
|Title=Association Between Two Genetic Variants in miRNA and Primary Liver Cancer Risk in the Chinese Population
|OA=1
}}

{{PMID Auto
|PMID=22218224
|Title=Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene
|OA=1
}}

{{PMID Auto
|PMID=22282540
|Title=Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24
|OA=1
}}

{{PMID Auto
|PMID=22182931
|Title=Association between the rs2910164 polymorphism in pre-mir-146a and oral carcinoma progression.
}}

{{PMID Auto
|PMID=22291993
|Title=A Genetic Variant in miR-196a2 Increased Digestive System Cancer Risks: A Meta-Analysis of 15 Case-Control Studies
|OA=1
}}

{{PMID Auto
|PMID=22363415
|Title=Differential Expression Profile and Genetic Variants of MicroRNAs Sequences in Breast Cancer Patients
|OA=1
}}

{{PMID Auto
|PMID=22363684
|Title=Increased Risk of Breast Cancer Associated with CC Genotype of Has-miR-146a Rs2910164 Polymorphism in Europeans
|OA=1
}}

{{PMID Auto
|PMID=22761848
|Title=Lack of Association of miR-146a rs2910164 Polymorphism with Gastrointestinal Cancers: Evidence from 10206 Subjects
|OA=1
}}

{{PMID Auto
|PMID=22823586
|Title=MiR-146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients
}}

{{PMID Auto
|PMID=18521189
|Title=Genetic variants of miRNA sequences and non-small cell lung cancer survival.
|OA=1
}}

{{PMID Auto
|PMID=18634034
|Title=Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women.
}}

{{PMID Auto
|PMID=19047128
|Title=Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.
|OA=1
}}

{{PMID Auto
|PMID=19138993
|Title=Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19164563
|Title=Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer.
|OA=1
}}

{{PMID Auto
|PMID=19232555
|Title=Signatures of purifying and local positive selection in human miRNAs.
|OA=1
}}

{{PMID Auto
|PMID=19290790
|Title=MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine.
|OA=1
}}

{{PMID Auto
|PMID=19458495
|Title=Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes.
|OA=1
}}

{{PMID Auto
|PMID=19617315
|Title=SNPs in human miRNA genes affect biogenesis and function.
|OA=1
}}

{{PMID Auto
|PMID=19881472
|Title=Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis.
}}

{{PMID Auto
|PMID=20428464
|Title=MicroRNA polymorphisms: a giant leap towards personalized medicine.
|OA=1
}}

{{PMID Auto
|PMID=20520619
|Title=Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population.
}}

{{PMID Auto
|PMID=20721625
|Title=Combined effect of miR-146a rs2910164 G/C polymorphism and Toll-like receptor 4 +3725 G/C polymorphism on the risk of severe gastric atrophy in Japanese.
}}

{{PMID Auto
|PMID=20810544
|Title=Association between hsa-mir-146a genotype and tumor age-of-onset in BRCA1/BRCA2-negative familial breast and ovarian cancer patients.
}}

{{PMID Auto
|PMID=20845080
|Title=Association of pre-microRNAs genetic variants with susceptibility in systemic lupus erythematosus.
}}

{{PMID Auto
|PMID=21181275
|Title=Association study of single nucleotide polymorphisms in pre-miRNA and rheumatoid arthritis in a Han Chinese population.
}}

{{PMID Auto
|PMID=21319225
|Title=Common genetic polymorphisms in pre-microRNAs and risk of cervical squamous cell carcinoma.
}}

{{PMID Auto
|PMID=21345130
|Title=Investigative role of pre-microRNAs in bladder cancer patients: a case-control study in North India.
}}

{{PMID Auto
|PMID=21529907
|Title=Polymorphism of the pre-miR-146a is associated with risk of cervical cancer in a Chinese population.
}}

{{PMID Auto
|PMID=21663520
|Title=Association between single-nucleotide polymorphisms in pre-miRNAs and the risk of asthma in a Chinese population.
}}

{{PMID Auto
|PMID=21713406
|Title=Association between two single nucleotide polymorphisms at corresponding microRNA and schizophrenia in a Chinese population.
}}

{{PMID Auto
|PMID=21875645
|Title=Expression and genetic analysis of miRNAs involved in CD4+ cell activation in patients with multiple sclerosis.
}}

{{PMID Auto
|PMID=21902575
|Title=Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers.
}}

{{PMID Auto
|PMID=21947843
|Title=Has-miR-146a polymorphism (rs2910164) and cancer risk: a meta-analysis of 19 case-control studies.
}}

{{PMID Auto
|PMID=22019503
|Title=Association of polymorphisms in pre-miRNA with inflammatory biomarkers in rheumatoid arthritis in the Chinese Han population.
}}

{{PMID Auto
|PMID=23007982
|Title=Meta-analysis confirms that a  common  G/C variant in the pre-miR-146a gene contributes to cancer susceptibility and that ethnicity, gender and smoking status are risk factors
}}

{{PMID Auto
|PMID=22719192
|Title=Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer
|OA=1
}}

{{PMID Auto
|PMID=23138379
|Title=Association of pre-miRNA-146a rs2910164 and pre‑miRNA-499 rs3746444 polymorphisms and susceptibility to rheumatoid arthritis
}}

{{PMID Auto
|PMID=22818121
|Title=The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer
}}

{{PMID Auto
|PMID=23262343
|Title=Relationship between genetic variant in pre-microRNA-146a and genetic predisposition to Temporal Lobe Epilepsy: A case-control study
}}

{{PMID Auto
|PMID=23267167
|Title=Association of pre-miR-146a rs2910164 Polymorphism with the Risk of Head and Neck Cancer
}}

{{PMID Auto
|PMID=23268366
|Title=MicroRNA-146a and Ets-1 gene polymorphisms in ocular Behcet's disease and Vogt-Koyanagi-Harada syndrome
}}

{{PMID Auto
|PMID=23437296
|Title=The Association between Two Common Polymorphisms in MicroRNAs and Hepatocellular Carcinoma Risk in Asian Population
|OA=1
}}

{{PMID Auto
|PMID=23451063
|Title=Association between the rs2910164 Polymorphism in Pre-Mir-146a Sequence and Thyroid Carcinogenesis
|OA=1
}}

{{PMID Auto
|PMID=23470291
|Title=Association between Genetic Variants in Pre-MicroRNAs and Survival of Early-Stage NSCLC
}}

{{PMID Auto
|PMID=23534761
|Title=The miR-146a rs2910164 G &gt; C Polymorphism and Susceptibility to Digestive Cancer in Chinese
}}

{{PMID Auto
|PMID=23545308
|Title=Association between miR-146a rs2910164 Polymorphism and Autoimmune diseases susceptibility: a meta-analysis
}}

{{PMID Auto
|PMID=23219900
|Title=Pre-microRNA variants predict HPV16-positive tumors and survival in patients with squamous cell carcinoma of the oropharynx
|OA=1
}}

{{PMID Auto
|PMID=23613822
|Title=Genetic Polymorphisms of miR-146a and miR-27a, H. pylori Infection, and Risk of Gastric Lesions in a Chinese Population
|OA=1
}}

{{PMID Auto
|PMID=23613771
|Title=Polymorphisms of microRNA Sequences or Binding Sites and Lung Cancer: A Meta-Analysis and Systematic Review
|OA=1
}}

{{PMID Auto
|PMID=23728616
|Title=Association between genetic variants in pre-miRNA and colorectal cancer risk in a Chinese population
}}

{{PMID Auto
|PMID=23888320
|Title=A functional polymorphism in the miR-146a gene is associated with the risk of childhood acute lymphoblastic leukemia: a preliminary report
}}

{{PMID Auto
|PMID=24102488
|Title=Meta-analysis of pre-miRNA polymorphisms association with susceptibility to autoimmune diseases
}}

{{PMID Auto
|PMID=24136745
|Title=Association between microRNA genetic variants and susceptibility to colorectal cancer in Chinese population
}}

{{PMID Auto
|PMID=23791656
|Title=Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: a systematic review and meta-analysis
}}

{{PMID Auto
|PMID=24301908
|Title=miR-499A&gt;G rs3746444 and miR-146aG&gt;C expression and hepatocellular carcinoma risk in the Chinese population
}}

{{PMID Auto
|PMID=24413317
|Title=MicroRNA sequence polymorphisms and the risk of different types of cancer
}}

{{PMID Auto
|PMID=24447667
|Title=A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression
}}

{{PMID Auto
|PMID=24502829
|Title=Has-mir-146a rs2910164 polymorphism and risk of immune thrombocytopenia
}}

{{PMID Auto
|PMID=24528016
|Title=A Genetic Variant in MiR-146a Modifies Digestive System Cancer Risk: a Meta-analysis
}}

{{PMID Auto
|PMID=24568449
|Title=Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a, miR-149 and miR-499 with Colorectal Cancer Susceptibility
}}

{{PMID Auto
|PMID=22659075
|Title=Association of the miR-146aC>G, miR-196a2C>T, and miR-499A>G polymorphisms with moyamoya disease in the Korean population.
}}

{{PMID Auto
|PMID=22711332
|Title=A single nucleotide polymorphism in microRNA-146a is associated with the risk for nasopharyngeal carcinoma.
}}

{{PMID Auto
|PMID=22846912
|Title=Genetic variants in miRNAs predict bladder cancer risk and recurrence.
}}

{{PMID Auto
|PMID=22926736
|Title=Low penetrance alleles as risk modifiers in familial and sporadic breast cancer.
}}

{{PMID Auto
|PMID=23001871
|Title=Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G polymorphisms with gastric cancer risk and survival in the Korean population.
}}

{{PMID Auto
|PMID=23020128
|Title=The miR-146a rs2910164 C/G polymorphism is associated with telangiectasia in systemic sclerosis.
}}

{{PMID Auto
|PMID=23222547
|Title=The rs2910164 G>C polymorphism in microRNA-146a is associated with the incidence of malignant melanoma.
}}

{{PMID Auto
|PMID=23292097
|Title=Effects of common polymorphisms rs2910164 in miR-146a and rs3746444 in miR-499 on cancer susceptibility: a meta-analysis.
}}

{{PMID Auto
|PMID=23292505
|Title=Association of a single-nucleotide polymorphism within the miR-146a gene with susceptibility for acute-on-chronic hepatitis B liver failure.
}}

{{PMID Auto
|PMID=23306950
|Title=A genetic variant in miR-146a modifies colorectal cancer susceptibility in a Chinese population.
}}

{{PMID Auto
|PMID=23543085
|Title=Association study of genetic variants in miRNAs in patients with inflammatory bowel disease: preliminary results.
}}

{{PMID Auto
|PMID=23593385
|Title=Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=23731641
|Title=Association of microRNAs genes polymorphisms with rheumatoid arthritis in Egyptian female patients.
}}

{{PMID Auto
|PMID=23794009
|Title=miR-146a polymorphism influences levels of miR-146a, IRAK-1, and TRAF-6 in young patients with coronary artery disease.
}}

{{PMID Auto
|PMID=24803388
|Title=Association of miR-146a polymorphisms with systemic lupus erythematosus: a meta-analysis
}}

{{PMID Auto
|PMID=24039706
|Title=The associations of single nucleotide polymorphisms in miR-146a, miR-196a and miR-499 with breast cancer susceptibility
}}

{{PMID Auto
|PMID=24916311
|Title=MicroRNAs related polymorphisms and genetic susceptibility to esophageal squamous cell carcinoma
}}

{{PMID Auto
|PMID=24978643
|Title=Genetic variants of MicroRNA-related genes in susceptibility and prognosis of end-stage renal disease and renal allograft outcome among north Indians
}}

{{PMID Auto
|PMID=25053223
|Title=A micro RNA-146a polymorphism is associated with coronary restenosis
}}

{{PMID Auto
|PMID=25084752
|Title=Association between genetic variant in hsa-miR-146a gene and prostate cancer progression: evidence from Serbian population
}}

{{PMID Auto
|PMID=25154761
|Title=MicroRNA-146a rs2910164 polymorphism is associated with susceptibility to non-small cell lung cancer in the Chinese population
}}

{{PMID Auto
|PMID=25209759
|Title=A single-nucleotide polymorphism of miR-146a and psoriasis: an association and functional study
}}

{{PMID Auto
|PMID=25213291
|Title=Genetic Polymorphisms in miRNAs and Susceptibility to Colorectal Cancer
}}

{{PMID Auto
|PMID=25218914
|Title=Comprehensive Review of Genetic Association Studies and Meta-analysis on miRNA polymorphisms and rheumatoid arthritis and systemic lupus erythematosus susceptibility
}}

{{PMID Auto
|PMID=24681820
|Title=Genetic variations in microRNAs and the risk and survival of renal cell cancer
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}