{{Rsnum
|rsid=2943634
|Chromosome=2
|position=226203364
|Orientation=plus
|GMAF=0.3214
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 13.3 | 42.5 | 44.2
| HCB | 0.7 | 16.8 | 82.5
| JPT | 0.0 | 16.8 | 83.2
| YRI | 33.3 | 50.3 | 16.3
| ASW | 31.6 | 40.4 | 28.1
| CHB | 0.7 | 16.8 | 82.5
| CHD | 1.9 | 13.0 | 85.2
| GIH | 2.0 | 34.7 | 63.4
| LWK | 43.6 | 42.7 | 13.6
| MEX | 0.0 | 34.5 | 65.5
| MKK | 38.5 | 46.8 | 14.7
| TSI | 12.7 | 45.1 | 42.2
| HapMapRevision=28
}}
[[rs2943634]] is a SNP found to be reproducibly associated with [[heart disease]] {{PMID|17634449|OA=1
}}
{{PMID|18979498|OA=1
}} [[rs2943634]] associated with high density lipoprotein (HDL) [[cholesterol]]

{{GWAS Summary
|SNP=rs2943634
|PubMedID=17634449
|Condition=Coronary disease
|Gene=pseudogene
|Risk Allele=C
|pValue=2.00E-007
|OR=1.21
|95CI=1.13-1.30
|OA=1
}}

{{PMID Auto
|PMID=19164808
|Title=Large scale association analysis of novel genetic loci for coronary artery disease
|OA=1
}}

{{PMID Auto
|PMID=18675980
|Title=Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes
|OA=1
}}

{{PharmGKB
|RSID=rs2943634
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17634449; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genomewide association analysis of coronary artery disease (Initial Sample Size: 1,926 cases, 2,938 controls; Replication Sample Size: 875 cases, 1,644 controls; Risk Allele: rs2943634-C).
|Drugs=
|Drug Classes=
|Diseases=Coronary Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356674
}}

{{PMID Auto
|PMID=19373437
|Title=Association of three polymorphisms selected from a genome-wide association study with coronary heart disease in the Tunisian population
}}

{{PMID Auto
|PMID=21463265
|Title=Association of SNP rs17465637 on Chromosome 1q41 and rs599839 on 1p13.3 with Myocardial Infarction in an American Caucasian Population
|OA=1
}}

{{PMID Auto
|PMID=22207032
|Title=Significant associations of the rs2943634 (2q36.3) genetic polymorphism with adiponectin, high density lipoprotein cholesterol and ischemic stroke
}}

{{PMID|18780302|OA=1
}} Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.

{{PMID|19135198}} Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease.

{{PMID|19198609|OA=1
}} Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

{{PMID|19750184|OA=1
}} Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

{{PMID|19956433|OA=1
}} Genetics of coronary artery disease: focus on genome-wide association studies.

{{PMID|20017983|OA=1
}} Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.

{{PMID|21804106|OA=1
}} Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.

{{PMID|22042884|OA=1
}} Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.

{{PMID Auto GWAS
|PMID=22581228
|Trait=None
|Title=A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|RiskAllele=
|Pval=2E-14
|OR=None
|ORtxt=None
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2943634
|overall_frequency_n=74
|overall_frequency_d=124
|overall_frequency=0.596774
|n_genomes=41
|n_genomes_annotated=0
|n_haplomes=66
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23101478
|Title=Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study
|OA=1
}}

{{PMID Auto
|PMID=23659870
|Title=Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study
}}

{{PMID Auto
|PMID=22797928
|Title=Evidence of selection at insulin receptor substrate-1 gene loci.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}