{{Rsnum
|rsid=2943641
|Chromosome=2
|position=226229029
|Orientation=plus
|GMAF=0.2686
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 41.6 | 43.4 | 15.0
| HCB | 89.1 | 10.9 | 0.0
| JPT | 86.7 | 13.3 | 0.0
| YRI | 57.1 | 38.8 | 4.1
| ASW | 47.4 | 47.4 | 5.3
| CHB | 89.1 | 10.9 | 0.0
| CHD | 89.0 | 11.0 | 0.0
| GIH | 53.5 | 40.6 | 5.9
| LWK | 31.8 | 51.8 | 16.4
| MEX | 63.8 | 34.5 | 1.7
| MKK | 34.0 | 50.6 | 15.4
| TSI | 36.3 | 51.0 | 12.7
| HapMapRevision=28
}}
{{PMID Auto
|PMID=19734900
|Title=Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
}}

{{doi|10.1371/journal.pone.0026911}} identified a significant association of rs2943641 near IRS1 locus, with type 2 diabetes in the Japanese population.

{{omim
|id=147545
|rsnum=2943641
}}

{{PMID Auto
|PMID=22576021
|Title=Association study of a common variant near IRS1 with type 2 diabetes mellitus in Chinese Han population
}}

{{PMID Auto
|PMID=21917432
|Title=IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.
|OA=1
}}

{{PMID Auto
|PMID=22253814
|Title=A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme
|OA=1
}}

{{PMID|20043853|OA=1
}} Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.

{{PMID|21353221|OA=1
}} The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects.

{{PMID|21747052|OA=1
}} Insulin receptor substrate 1 gene variation modifies insulin resistance response to weight-loss diets in a 2-year randomized trial: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2943641
|overall_frequency_n=91
|overall_frequency_d=128
|overall_frequency=0.710938
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=81
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23418314
|Title=The IRS1 rs2943641 Variant and Risk of Future Cancer Among Morbidly Obese Individuals
}}

{{PMID Auto
|PMID=23036851
|Title=Treatment factors rather than genetic variation determine metabolic syndrome in childhood cancer survivors
}}

{{PMID Auto
|PMID=23659870
|Title=Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study
}}

{{PMID Auto
|PMID=24255076
|Title=Circulating 25-Hydroxyvitamin D, IRS1 Variant rs2943641, and Insulin Resistance: Replication of a Gene-Nutrient Interaction in 4 Populations of Different Ancestries
|OA=1
}}

{{PMID Auto
|PMID=24493031
|Title=Association of the genetic variants of insulin receptor substrate 1 (IRS-1) with type 2 diabetes mellitus in a Saudi population
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}