{{Rsnum
|rsid=2952768
|Chromosome=2
|position=207629510
|Orientation=plus
|GMAF=0.3581
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 13.8 | 48.6 | 37.6
| HCB | 16.1 | 47.4 | 36.5
| JPT | 12.4 | 40.7 | 46.9
| YRI | 6.8 | 38.8 | 54.4
| ASW | 8.8 | 40.4 | 50.9
| CHB | 16.1 | 47.4 | 36.5
| CHD | 11.0 | 53.2 | 35.8
| GIH | 24.0 | 48.0 | 28.0
| LWK | 16.5 | 44.0 | 39.4
| MEX | 20.7 | 32.8 | 46.6
| MKK | 8.3 | 50.6 | 41.0
| TSI | 11.8 | 42.2 | 46.1
| HapMapRevision=28
}}[http://www.nature.com/mp/journal/vaop/ncurrent/full/mp2012164a.html Genome-wide association study identifies a potent locus associated with human opioid sensitivity]

{{doi|10.1038/mp.2012.164}} rs2952768(C) was associated with more analgesic requirements ... exhibited less vulnerability to severe methamphetamine or [[alcohol  dependence]], fewer eating disorders, and a lower ‘Reward Dependence’ score on a personality questionnaire. The (C;C) genotype was significantly associated with the elevated expression of a neighboring gene, CREB.  SNPs in this locus are the most potent genetic factors associated with human opioid sensitivity known to date, affecting both the efficacy of opioid analgesics and liability to severe substance dependence.

Our findings provide valuable information for the personalized treatment of [[pain]] and drug dependence.

{{PMID Auto GWAS
  |PMID=23183491
  |Trait=Opioid sensitivity
  |Title=Genome-wide association study identifies a potent locus associated with human opioid sensitivity.
  |RiskAllele=C
  |Pval=8E-7
  |OR=.29
  |ORtxt=unit increase
  |OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}