{{Rsnum
|rsid=2953145
|Gene=RNPEPL1
|Chromosome=2
|position=240576179
|Orientation=minus
|GMAF=0.1437
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=RNPEPL1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 3.5 | 32.7 | 63.7
| HCB | 0.0 | 8.8 | 91.2
| JPT | 0.0 | 3.5 | 96.5
| YRI | 3.4 | 35.4 | 61.2
| ASW | 1.8 | 29.8 | 68.4
| CHB | 0.0 | 8.8 | 91.2
| CHD | 0.0 | 2.8 | 97.2
| GIH | 3.0 | 40.6 | 56.4
| LWK | 6.4 | 34.5 | 59.1
| MEX | 0.0 | 17.2 | 82.8
| MKK | 9.0 | 39.7 | 51.3
| TSI | 8.8 | 38.2 | 52.9
| HapMapRevision=28
}}
[[rs2953145]] has been reported in a large study to be associated with [[bipolar disorder]].

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.84 (CI 1.31-2.58), and for homozygotes, 2.14 (CI 1.53-2.98). {{PMID|17554300|OA=1
}}

{{GWAS Summary
|SNP=rs2953145
|PubMedID=17554300
|Condition=Bipolar disorder
|Gene=NR
|Risk Allele=C
|pValue=7.00E-006
|OR=1.84
|95CI=1.31-2.58
|OA=1
}}

{{PharmGKB
|RSID=rs2953145
|Name_s=
|Gene_s=RNPEPL1
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,868 cases, 2,938 controls; Replication Sample Size: NR; Risk Allele: rs2953145-C). This variant is associated with bipolar disorder.
|Drugs=
|Drug Classes=
|Diseases=Bipolar Disorder
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356651
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2953145
|overall_frequency_n=103
|overall_frequency_d=128
|overall_frequency=0.804688
|n_genomes=52
|n_genomes_annotated=0
|n_haplomes=88
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}