{{Rsnum
|rsid=2954029
|Chromosome=8
|position=125478730
|Orientation=plus
|GMAF=0.4412
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 33.8 | 56.9 | 9.2
| HCB | 17.8 | 46.7 | 35.6
| JPT | 22.7 | 47.7 | 29.5
| YRI | 49.2 | 44.4 | 6.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 17.8 | 46.7 | 35.6
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=24097068
|Trait=HDL cholesterol
|Title=Discovery and refinement of loci associated with lipid levels. 
|RiskAllele=T
|Pval=3E-29
|OR=0.04
|ORtxt=[NR] unit increase
}}
{{PMID Auto GWAS
|PMID=24097068
|Trait=LDL cholesterol
|Title=Discovery and refinement of loci associated with lipid levels. 
|RiskAllele=T
|Pval=2E-50
|OR=0.056
|ORtxt=[NR] unit decrease
}}
{{PMID Auto GWAS
|PMID=24097068
|Trait=Triglycerides
|Title=Discovery and refinement of loci associated with lipid levels. 
|RiskAllele=T
|Pval=1E-107
|OR=0.076
|ORtxt=[NR] mg/dL decrease
}}
{{PMID Auto GWAS
|PMID=20864672
|Trait=Triglycerides
|Title=Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
|RiskAllele=T
|Pval=2E-11
|OR=0.04
|ORtxt=[0.03-0.05] unit decrease
|OA=1
}}
{{PMID Auto GWAS
|PMID=20686565
|Trait=HDL cholesterol
|Title=Biological, clinical and population relevance of 95 loci for blood lipids.
|RiskAllele=T
|Pval=6E-19
|OR=0.61
|ORtxt=[0.47-0.75] mg/dL increase
|OA=1
}}
{{PMID Auto GWAS
|PMID=20686565
|Trait=LDL cholesterol
|Title=Biological, clinical and population relevance of 95 loci for blood lipids.
|RiskAllele=A
|Pval=3E-29
|OR=1.84
|ORtxt=[1.51-2.17] mg/dL decrease
|OA=1
}}
{{PMID Auto GWAS
|PMID=20686565
|Trait=Triglycerides
|Title=Biological, clinical and population relevance of 95 loci for blood lipids.
|RiskAllele=T
|Pval=3E-55
|OR=5.64
|ORtxt=[4.88-6.4] mg/dL decrease
|OA=1
}}
{{PMID Auto GWAS
|PMID=20139978
|Trait=Triglycerides
|Title=Genome-wide association study of hematological and biochemical traits in a Japanese population. 
|RiskAllele=T
|Pval=3E-7
|OR=0.076
|ORtxt=[0.047-0.105] unit decrease
}}
{{PMID Auto GWAS
|PMID=19060906
|Trait=Triglycerides
|Title=Common variants at 30 loci contribute to polygenic dyslipidemia
|RiskAllele=T
|Pval=3E-19
|OR=0.11
|ORtxt=[0.07-0.15] SD decrease
|OA=1
}}
{{PMID Auto GWAS
|PMID=19060906
|Trait=Triglycerides
|Title=Common variants at 30 loci contribute to polygenic dyslipidemia.  
|RiskAllele=T
|Pval=3E-19
|OR=0.11
|ORtxt=[0.07-0.15] s.d. decrease
}}

{{PharmGKB
|RSID=rs2954029
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 8q24.13; Reported Gene(s): TRIB1; Risk Allele: rs2954029-T); (p-value= 3E-19).This variant is associated with Triglycerides.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740263
}}
{{PMID Auto
|PMID=24922540
|Title=Genetic Determinants of Long-Term Changes in Blood Lipid Concentrations: 10-Year Follow-Up of the GLACIER Study
}}
{{PMID Auto
|PMID=23832694
|Title=Common genetic variants associated with lipid profiles in a Chinese pediatric population.
}}
{{PMID Auto
|PMID=23202125
|Title=Large-scale association analysis identifies new risk loci for coronary artery disease.
|OA=1
}}

{{PMID|21071687}} TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population.

{{PMID|20160193|OA=1
}} Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.
{{PMID Auto
|PMID=19656773
|Title=A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.
|OA=1
}}
{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2954029
|overall_frequency_n=43
|overall_frequency_d=128
|overall_frequency=0.335938
|n_genomes=30
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}