{{Rsnum
|rsid=2981578
|Gene=FGFR2
|Chromosome=10
|position=123340311
|Orientation=minus
|GMAF=0.3779
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 29.2 | 44.6 | 26.2
| HCB | 17.8 | 53.3 | 28.9
| JPT | 31.8 | 50.0 | 18.2
| YRI | 1.6 | 9.5 | 88.9
| ASW | 0.0 | 0.0 | 0.0
| CHB | 17.8 | 53.3 | 28.9
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[[rs2981578]] is a SNP within intron 2 of the [[FGFR2]] gene, as part of a haplotype associated with increased risk for sporadic postmenopausal ER+ [[breast cancer]] in Caucasian patients. The risk shown for this SNP is actually the risk calculated for the tightly associated SNP [[rs1219648]].{{PMID|17529973|OA=1
}}

The distinguishing feature of [[rs2981578]] is experimental evidence indicating that it is one of two SNPs in this intron that appear to have a (the?) functional role associated with the transcriptional regulation of the [[FGFR2]] gene. The minor alleles of both SNPs, [[rs2981578]] and [[rs7895676]], lead to increased transcription and increased [[breast cancer]] risk.{{doi|10.1371/journal.pbio.0060108}}

{{omim
|desc=FIBROBLAST GROWTH FACTOR RECEPTOR 2; FGFR2
|id=176943
|rsnum=2981578
}}

{{PMID Auto
|PMID=21767389
|Title=Allele-Specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10
|OA=1
}}

{{PMID Auto
|PMID=21822685
|Title=Genetic variants of fibroblast growth factor receptor 2 (FGFR2) are associated with breast cancer risk in Chinese women of the Han nationality
}}

{{PMID Auto
|PMID=22287734
|Title=Evaluation of Breast Cancer Susceptibility Loci on 2q35, 3p24, 17q23 and FGFR2 Genes in Taiwanese Women with Breast Cancer
}}

{{PMID Auto
|PMID=22357627
|Title=Evaluation of 19 Susceptibility Loci of Breast Cancer in Women of African Ancestry
|OA=1
}}

{{PMID|18285324|OA=1
}} Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk.

{{PMID|18462018|OA=1
}} Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer.

{{PMID|19223389|OA=1
}} FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation.

{{PMID|19434427|OA=1
}} Analytical methods for inferring functional effects of single base pair substitutions in human cancers.

{{PMID|19497954|OA=1
}} Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer.

{{PMID Auto
|PMID=24265722
|Title=Functional Analysis of a Breast Cancer-Associated FGFR2 Single Nucleotide Polymorphism Using Zinc Finger Mediated Genome Editing
|OA=1
}}

{{PMID Auto
|PMID=23124475
|Title=Three novel functional polymorphisms in the promoter of FGFR2 gene and breast cancer risk: a HuGE review and meta-analysis.
}}

{{PMID Auto GWAS
  |PMID=24143190
  |Trait=Breast cancer
  |Title=Genome-wide association study of breast cancer in the Japanese population.
  |RiskAllele=C
  |Pval=1E-12
  |OR=1.23
  |ORtxt=[1.158-1.296]
  |OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}