{{Rsnum
|rsid=2981579
|Gene=FGFR2
|Chromosome=10
|position=123337335
|Orientation=minus
|GMAF=0.4853
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 34.5 | 38.1 | 27.4
| HCB | 33.1 | 44.9 | 22.1
| JPT | 35.4 | 47.8 | 16.8
| YRI | 13.6 | 44.2 | 42.2
| ASW | 12.3 | 49.1 | 38.6
| CHB | 33.1 | 44.9 | 22.1
| CHD | 35.8 | 46.8 | 17.4
| GIH | 30.7 | 53.5 | 15.8
| LWK | 13.6 | 50.0 | 36.4
| MEX | 29.3 | 50.0 | 20.7
| MKK | 16.0 | 45.5 | 38.5
| TSI | 26.5 | 48.0 | 25.5
| HapMapRevision=28
}}
This SNP is basically a proxy for SNP [[rs1219648]], which represents the SNP in the [[FGFR2]] gene with the strongest association with [[breast cancer]]. {Note: the alleles shown for this SNP in SNPedia are in orientation to the dbSNP entry, not as published.] {{PMID|17529973|OA=1
}}

{{PMID Auto GWAS
|PMID=19330030
|Trait=Breast cancer
|Title=A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
|RiskAllele=T
|Pval=2E-10
|OA=1
}}

{{PharmGKB
|RSID=rs2981579
|Name_s=
|Gene_s=FGFR2
|Feature=
|Evidence=PubMed ID:19330030; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A multistage genome-wide association study in Breast Cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). (Initial Sample Size: 1,145 cases, 1,142 controls; Replication Sample Size: 8,625 cases, 9,657 controls); (Region: 10q26.13; Reported Gene(s): FGFR2; Risk Allele: rs2981579-T); (p-value= 0.0000000002).This variant is associated with Breast Cancer.
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739880
}}

{{PMID Auto GWAS
|PMID=20453838
|Trait=Breast cancer
|Title=Genome-wide association study identifies five new breast cancer susceptibility loci
|RiskAllele=A
|Pval=4E-31
|OR=1.43
|ORtxt=[1.35-1.53]
|OA=1
}}

{{PMID Auto
|PMID=21445572
|Title=Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
}}

{{PMID|18285324|OA=1
}} Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk.

{{PMID|18326623|OA=1
}} Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.

{{PMID|19497954|OA=1
}} Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer.

{{PMID|19500394|OA=1
}} Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study.

{{PMID|20554749|OA=1
}} FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women.

{{PMID|22160591}} A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2981579
|overall_frequency_n=61
|overall_frequency_d=128
|overall_frequency=0.476562
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=50
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23535729
  |Trait=Breast cancer
  |Title=Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
  |RiskAllele=A
  |Pval=2E-170
  |OR=1.27
  |ORtxt=[1.24-1.29]
  |OA=1
}}

{{PMID Auto
|PMID=24454457
|Title=Case-control study on the fibroblast growth factor receptor 2 gene polymorphisms associated with breast cancer in chinese han women
|OA=1
}}

{{PMID Auto
|PMID=22965832
|Title=Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population.
}}

{{PMID Auto
|PMID=23124475
|Title=Three novel functional polymorphisms in the promoter of FGFR2 gene and breast cancer risk: a HuGE review and meta-analysis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}