{{Rsnum
|rsid=299290
|Gene=HMMR
|Chromosome=5
|position=163475510
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.3223
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=HMMR
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 6.2 | 44.6 | 49.1
| HCB | 16.1 | 50.4 | 33.6
| JPT | 30.1 | 47.8 | 22.1
| YRI | 6.1 | 45.6 | 48.3
| ASW | 8.8 | 49.1 | 42.1
| CHB | 16.1 | 50.4 | 33.6
| CHD | 20.4 | 44.4 | 35.2
| GIH | 3.0 | 34.7 | 62.4
| LWK | 2.7 | 30.9 | 66.4
| MEX | 10.5 | 52.6 | 36.8
| MKK | 0.6 | 16.8 | 82.6
| TSI | 6.9 | 34.3 | 58.8
| HapMapRevision=28
}}[http://cancergenetics.wordpress.com/2007/10/13/exciting-discoveries-of-2007-breast-cancer/ cancergenetics] The risk of [[breast cancer]] was 23% higher in women who had one copy of genetic variant (the A-C-A haplotype: [[rs7712023]]-[[rs299290]]-[[rs10515860]]), and 46% higher in women with two copies. In addition, those women were diagnosed an average of 12 months younger than women from the control group, suggesting that [[HMMR]] is linked to early-onset breast cancer.

However, a more recent, larger European case-control study found no association between [[rs299290]] and risk of breast cancer.{{PMID|19065580}} 

{{PMID|19064580}} [[breast cancer]]
*[[rs10515860]] [odds ratio (OR; AA/GG), 0.85; 95% confidence interval (CI), 0.65-1.12; P(trend) = 0.9], 
*[[rs299290]] [OR (CC/TT), 1.00; 95% CI, 0.87-1.15; P(trend) = 0.7], 
*[[rs3756648]] ([[rs7712023]]) [OR (TT/CC), 0.93; 95% CI, 0.84-1.02; P(trend) = 0.1], 
*[[rs299284]] [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; P(trend) = 0.5], and 
*[[rs13183712]] [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; P(trend) = 0.6].

{{GET Evidence
|gene=HMMR
|aa_change=Val369Ala
|aa_change_short=V369A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs299290
|overall_frequency_n=2835
|overall_frequency_d=10758
|overall_frequency=0.263525
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=4
|n_articles=0
|n_articles_annotated=0
|nblosum100=2
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}