{{Rsnum
|rsid=3020781
|Gene=PKLR
|Chromosome=1
|position=155269776
|Orientation=minus
|GMAF=0.4908
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 10.8 | 41.5 | 47.7
| HCB | 44.4 | 46.7 | 8.9
| JPT | 61.4 | 36.4 | 2.3
| YRI | 23.8 | 54.0 | 22.2
| ASW | 0.0 | 0.0 | 0.0
| CHB | 44.4 | 46.7 | 8.9
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}The C-allele of [[PKLR]] [[rs3020781]] was previously reported to be strongly associated with [[type-2 diabetes]] in various European-descent populations comprising a total of 2,198 individuals with a combined odds ratio (OR) of 1.33 [1.16-1.54].

However, in a combined study sample comprising a total of 16,801 and 16,913 individuals from Denmark, no significant association was found to diabetes or obesity.{{PMID|19111066|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}