{{Rsnum
|rsid=3024505
|Gene=IL10
|Chromosome=1
|position=206766559
|Orientation=minus
|GMAF=0.09091
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 65.5 | 32.7 | 1.8
| HCB | 95.6 | 4.4 | 0.0
| JPT | 99.1 | 0.9 | 0.0
| YRI | 94.6 | 5.4 | 0.0
| ASW | 94.6 | 5.4 | 0.0
| CHB | 95.6 | 4.4 | 0.0
| CHD | 94.5 | 5.5 | 0.0
| GIH | 68.0 | 30.0 | 2.0
| LWK | 89.6 | 9.4 | 0.9
| MEX | 91.4 | 8.6 | 0.0
| MKK | 96.6 | 2.0 | 1.3
| TSI | 65.3 | 30.7 | 4.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=18836448
|Trait=Ulcerative colitis
|Title=Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
|RiskAllele=T
|Pval=9.9999999999999998E-13
|OR=1.46
|ORtxt=[1.31-1.62]
}}

{{PMID Auto GWAS
|PMID=19430480
|Trait=Type 1 diabetes
|Title=Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
|RiskAllele=
|Pval=2E-9
|OR=1.19
|ORtxt=[1.10-1.30]
|OA=1
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 23; IBD23
|id=612381
|rsnum=3024505
}}

{{PharmGKB
|RSID=rs3024505
|Name_s=
|Gene_s=IL10
|Feature=
|Evidence=PubMed ID:18836448; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. (Initial Sample Size: 1,167 cases, 777 controls; Replication Sample Size: 1,855 cases, 3,091 controls); (Region: 1q32.1; Reported Gene: IL10; Risk Allele: rs3024505-T) This variant is associated with Ulcerative colitis.
|Drugs=
|Drug Classes=
|Diseases=Colitis, Ulcerative
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740884
}}

{{PMID Auto GWAS
|PMID=20228799
|Trait=Ulcerative colitis
|Title=Genome-wide association identifies multiple ulcerative colitis susceptibility loci
|RiskAllele=T
|Pval=1E-8
|OR=1.23
|ORtxt=[NR]
|OA=1
}}
{{PMID Auto
|PMID=20509889
|Title=The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study
|OA=1
}}

{{PharmGKB
|RSID=rs3024505
|Name_s=
|Gene_s=IL10
|Feature=
|Evidence=PubMed ID:18836448
|Annotation=A genome-wide association study in 1,167 individuals with ulcerative colitis and 777 healthy controls found significant association of this variant immediately flanking the IL10 gene and ulcerative colitis.
|Drugs=
|Drug Classes=
|Diseases=Colitis, Ulcerative
|Curation Level=Curated
|PharmGKB Accession ID=PA162355781
}}

{{PharmGKB
|RSID=rs3024505
|Name_s=
|Gene_s=IL10
|Feature=
|Evidence=PubMed ID:18836448; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. (Initial Sample Size: 1,167 cases, 777 controls; Replication Sample Size: 1,855 cases, 3,091 controls); (Region: 1q32.1; Reported Gene(s): IL10; Risk Allele: rs3024505-T); (p-value= 9.99999999999999E-13).This variant is associated with Ulcerative colitis.
|Drugs=
|Drug Classes=
|Diseases=Colitis, Ulcerative
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740842
}}

{{PMID Auto GWAS
|PMID=21102463
|Trait=None
|Title=Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
|RiskAllele=T
|Pval=2E-14
|OR=1.1200
|ORtxt=[1.07-1.17]
|OA=1
}}
{{omim
|id=222100
|rsnum=3024505
}}

{{PMID Auto GWAS
|PMID=21297633
|Trait=None
|Title=Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
|RiskAllele=A
|Pval=6E-17
|OR=1.2500
|ORtxt=[1.19-1.32]
|OA=1
}}

{{PMID Auto GWAS
|PMID=21829393
|Trait=None
|Title=Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|RiskAllele=G
|Pval=5E-10
|OR=1.2000
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto
|PMID=22594912
|Title=Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study
|OA=1
}}

{{PMID Auto
|PMID=19468064
|Title=Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.
|OA=1
}}

{{PMID Auto
|PMID=19505919
|Title=Toll-like receptor signaling pathway variants and prostate cancer mortality.
|OA=1
}}

{{PMID Auto
|PMID=19698145
|Title=Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.
|OA=1
}}

{{PMID Auto
|PMID=19776214
|Title=SimCT: a generic tool to visualize ontology-based relationships for biological objects.
|OA=1
}}

{{PMID Auto
|PMID=19838195
|Title=A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|OA=1
}}

{{PMID Auto
|PMID=20444268
|Title=Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.
|OA=1
}}

{{PMID Auto
|PMID=21245992
|Title=Polymorphisms in NF-kappaB, PXR, LXR, PPARgamma and risk of inflammatory bowel disease.
|OA=1
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{PMID Auto
|PMID=21354456
|Title=The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population.
}}

{{PMID Auto
|PMID=21379322
|Title=Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes.
|OA=1
}}

{{PMID Auto
|PMID=21408207
|Title=Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3024505
|overall_frequency_n=14
|overall_frequency_d=128
|overall_frequency=0.109375
|n_genomes=9
|n_genomes_annotated=0
|n_haplomes=9
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23128233
  |Trait=Inflammatory bowel disease
  |Title=Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
  |RiskAllele=A
  |Pval=7E-42
  |OR=1.21
  |ORtxt=[1.163-1.254]
  |OA=1
}}

{{PMID Auto
|PMID=24130510
|Title=Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 Expression
|OA=1
}}

{{PMID Auto
|PMID=24194923
|Title=Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study
|OA=1
}}

{{PMID Auto
|PMID=23348120
|Title=Genetic susceptibility in IBD: overlap between ulcerative colitis and Crohn's disease.
}}

{{PMID Auto
|PMID=24971461
|Title=Polymorphisms in the Inflammatory Pathway Genes TLR2, TLR4, TLR9, LY96, NFKBIA, NFKB1, TNFA, TNFRSF1A, IL6R, IL10, IL23R, PTPN22, and PPARG Are Associated with Susceptibility of Inflammatory Bowel Disease in a Danish Cohort
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}