{{Rsnum
|rsid=3025039
|Gene=VEGFA
|Chromosome=6
|position=43784799
|Orientation=plus
|GMAF=0.1492
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=VEGFA
}}[[rs3025039]], also known as the +936C/T SNP in the [[VEGFA]] gene, has been associated with age-related macular degeneration (ARMD).

A study of 190 Taiwanese patients with late wet [[age related macular degeneration]] found that the [[rs3025039]](T) allele was associated with increased risk, with an odds ratio of 2.61 (CI: 1.68 to 4.07, p = 1.45 x 10e-5).{{PMID|18378209}}

Note that this association may be completely due to the tight linkage (D' = 0.99) between this SNP and [[rs1061170]], which has been reported by numerous studies to be associated with ARMD.

{{PMID Auto
|PMID=19594543
|Title=Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer
}}
{{PMID Auto
|PMID=19875757
|Title=Clinical relevance of vascular endothelial growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism on the treatment outcome following imatinib therapy
}}

{{PharmGKB
|RSID=rs3025039
|Name_s=VEGFA:C936T
|Gene_s=VEGFA
|Feature=
|Evidence=PubMed ID:18223238
|Annotation=This SNP was not associated with risk of non-small cell lung cancer.
|Drugs=
|Drug Classes=
|Diseases=Carcinoma, Non-Small-Cell Lung
|Curation Level=Curated
|PharmGKB Accession ID=PA164891514
}}

{{PMID Auto
|PMID=20082870
|Title=A Single Nucleotide Polymorphism in the Vascular Endothelial Growth Factor Gene Is Associated with Recurrence of Hepatocellular Carcinoma after Transplantation
}}

{{PMID Auto
|PMID=20847577
|Title=Vascular Endothelial Growth Factor Gene Polymorphisms and Risk of Neovascular Age-Related Macular Degeneration in a Chinese Cohort
}}

C->T was associated with increased risk for altitude sickness. {{PMID Auto
|PMID=21242666
|Title=Polymorphisms of Hypoxia-Related Genes in Subjects Susceptible to Acute Mountain Sickness
|Annotation=C->T was associated with increased risk for altitude sickness.
}}

{{PMID Auto
|PMID=22129133
|Title=VEGFA and VEGFR2 genetic polymorphisms and survival in patients with diffuse large B cell lymphoma
}}

{{PMID Auto
|PMID=22315135
|Title=The single-nucleotide polymorphisms +936 C/T VEGF and -710 C/T VEGFR1 are associated with breast cancer protection in a Spanish population
}}

{{PMID Auto
|PMID=22439647
|Title=The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure - one institution study
|OA=1
}}

{{PMID Auto
|PMID=22162628
|Title=Polymorphisms in the vascular endothelial growth factor gene and the risk of diabetic retinopathy in Chinese patients with type 2 diabetes
|OA=1
}}

{{PMID Auto
|PMID=21905000
|Title=Disruption of vascular homeostasis in Kawasaki Disease patients: Involvement of vascular endothelial growth factor and angiopoietins.
}}

{{PMID Auto
|PMID=22818823
|Title=Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients
}}

{{PMID|15338501}} Vascular endothelial growth factor gene polymorphisms in Behcet's disease.

{{PMID|16613616|OA=1
}} Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort.

{{PMID|16645995}} Vascular endothelial growth factor gene haplotypes in Kawasaki disease.

{{PMID|17204151|OA=1
}} VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis.

{{PMID|17319747|OA=1
}} Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk.

{{PMID|17601350|OA=1
}} A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

{{PMID|17983459}} Vascular endothelial growth factor (VEGF) gene (VEGFA) polymorphism can predict the prognosis in acute myeloid leukaemia patients.

{{PMID|18281657}} VEGF polymorphisms and survival in early-stage non-small-cell lung cancer.

{{PMID|18650217}} Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis.

{{PMID|18676870|OA=1
}} Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

{{PMID|18780893|OA=1
}} Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk.

{{PMID|18805939|OA=1
}} Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

{{PMID|19041064}} Vascular endothelial growth factor gene polymorphisms may predict the risk of acute graft-versus-host disease following allogeneic transplantation: preventive effect of vascular endothelial growth factor gene on acute graft-versus-host disease.

{{PMID|19089753}} Variation in the vascular endothelial growth factor gene, carotid intima-media thickness and the risk of acute myocardial infarction.

{{PMID|19196101}} Combinational polymorphisms of seven CXCL12-related genes are protective against breast cancer in Taiwan.

{{PMID|19372140|OA=1
}} EGFR pathway polymorphisms and bladder cancer susceptibility and prognosis.

{{PMID|19438866|OA=1
}} Polymorphisms in genes involved in DNA repair, cell growth, oxidative stress and inflammatory response, and melanoma risk.

{{PMID|19496079}} Effect of polymorphisms in the 3' untranslated region (3'-UTR) of vascular endothelial growth factor gene on gastric cancer and peptic ulcer diseases in Japan.

{{PMID|19566948|OA=1
}} Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.

{{PMID|19584152|OA=1
}} Vascular endothelial growth factor polymorphisms and esophageal cancer prognosis.

{{PMID|19603096|OA=1
}} An analysis of growth, differentiation and apoptosis genes with risk of renal cancer.

{{PMID|19628492}} Polymorphism of the manganese superoxide dismutase gene but not of vascular endothelial growth factor gene is a risk factor for diabetic retinopathy.

{{PMID|19755511|OA=1
}} The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors.

{{PMID|19787077|OA=1
}} Association of vascular endothelial growth factor polymorphisms with asthma in Tunisian children.

{{PMID|19835575|OA=1
}} The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.

{{PMID|20019880|OA=1
}} Polymorphisms in the VEGFA and VEGFR-2 genes and neovascular age-related macular degeneration.

{{PMID|20389299|OA=1
}} Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

{{PMID|20540786|OA=1
}} The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. SLC2A1 polymorphisms and FDG-PET in NSCLC patients.

{{PMID|21080079}} Gene polymorphism of vascular endothelial growth factor -1154 G>A is associated with hypertensive nephropathy in a Hispanic population.

{{PMID|21245770}} Vascular endothelial growth factor gene polymorphisms and rheumatoid arthritis.

{{PMID|21347390|OA=1
}} Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms.

{{PMID|21362767}} Interaction between smoking and polymorphism in the promoter region of the VEGFA gene is associated with ischemic heart disease and myocardial infarction in rheumatoid arthritis.

{{PMID|21982816}} Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population.

{{PMID|22139971}} Vascular endothelial growth factor (VEGF) gene polymorphisms may influence the efficacy of thalidomide in multiple myeloma.

{{PMID|22320189|OA=1
}} Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy.

{{PMID|22429695}} Polymorphism in the vascular endothelial growth factor A (VEGFA) gene is associated with serum VEGF-A level and disease activity in rheumatoid arthritis: differential effect of cigarette smoking.

{{PMID|22521084}} Role of Vascular Endothelial Growth Factor Polymorphisms in the Treatment Success in Patients with Wet Age-related Macular Degeneration.

{{PMID Auto
|PMID=23073296
|Title=VEGF Polymorphisms are not associated with an Increased Risk of Developing Renal Cell Carcinoma in Spanish population
}}

{{PMID Auto
|PMID=23211130
|Title=Polymorphisms in the vascular endothelial growth factor gene associated with recurrent spontaneous miscarriage
}}

{{PMID Auto
|PMID=22776467
|Title=Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes
}}

{{PMID Auto
|PMID=23631762
|Title=Genotyping analysis and 18FDG uptake in breast cancer patients: a preliminary research
|OA=1
}}

{{PMID Auto
|PMID=23848209
|Title=Vascular endothelial growth factor A (VEGFA) polymorphisms in Chinese patients with rheumatoid arthritis
}}

{{PMID Auto
|PMID=23880405
|Title=Methionine sulfoxide reductase A rs10903323 G/A polymorphism is associated with increased risk of coronary artery disease in a Chinese population
}}

{{PMID Auto
|PMID=24353087
|Title=Assessment of the associations between three VEGF polymorphisms and risk of prostate cancer
}}

{{PMID Auto
|PMID=22491902
|Title=The interaction between the maternal BMI and angiogenic gene polymorphisms associates with the risk of spontaneous preterm birth.
}}

{{PMID Auto
|PMID=22729570
|Title=AKT3, ANGPTL4, eNOS3, and VEGFA associations with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.
}}

{{PMID Auto
|PMID=22925497
|Title=The relation of vascular endothelial growth factor (VEGF) gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle cell disease.
}}

{{PMID Auto
|PMID=23061744
|Title=Association of the vascular endothelial growth factor gene polymorphisms (-460C/T, +405G/C and +936T/C) with endometriosis: a meta-analysis.
}}

{{PMID Auto
|PMID=23102494
|Title=Vascular endothelial growth factor family gene polymorphisms in preeclampsia in Sinhalese women in Sri-Lanka.
}}

{{PMID Auto
|PMID=23264084
|Title=Positive association of the vascular endothelial growth factor-A +405 GG genotype and poor survival in stage I-II gastric cancer in the Northern Chinese population.
}}

{{PMID Auto
|PMID=23545315
|Title=Further evidence for the contribution of the vascular endothelial growth factor gene in coronary artery disease susceptibility.
}}

{{PMID Auto
|PMID=23586368
|Title=Vascular endothelial growth factor 936 c>T polymorphism increased oral cancer risk: evidence from a meta-analysis.
}}

{{PMID Auto
|PMID=23625573
|Title=A common and functional gene variant in the vascular endothelial growth factor a predicts clinical outcome in early-stage breast cancer.
}}

{{PMID Auto
|PMID=23644986
|Title=Genetic polymorphisms of vascular endothelial growth factor and risk for retinopathy of prematurity in South of Iran.
}}

{{PMID Auto
|PMID=24868559
|Title=The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies
}}

{{PMID Auto
|PMID=24940484
|Title=Association between vascular endothelial growth factor gene polymorphisms and bladder cancer risk
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}