{{Rsnum
|rsid=3087456
|Gene=CIITA
|Chromosome=16
|position=10877045
|Orientation=plus
|GMAF=0.4027
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CIITA
}}This SNP has been linked to increased risk of [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16849401&query_hl=3&itool=pubmed_docsum  adrenal insufficiency]
However. there is mixed information regarding several other autoimmune diseases in a german population [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16426246&query_hl=10&itool=pubmed_docsum]

Promoter polymorphism [[rs3087456]] in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups.

{{PMID|19605748}} An evaluation of 4,000 UK RA patients did not show any risk associated with this SNP.

{{PMID|20942939|OA=1
}} A study of a Swedish cohort of 446 myasthenia gravis (MG) patients and 1866 controls found no significant association of the SNP with MG, either in the patient group as a whole or in any clinical subgroup.

{{omim
|desc=RHEUMATOID ARTHRITIS, SUSCEPTIBILITY TO
|id=600005
|rsnum=3087456
|variant=0007
}}

{{PMID Auto
|PMID=19317741
|Title=Autoimmune disease association signals in CIITA and KIAA0350 are not involved in celiac disease susceptibility
}}

{{PMID Auto
|PMID=20230522
|Title=Major histocompatibility complex class II transactivator gene polymorphism: associations with L&#xF6;fgren's syndrome
}}

{{PMID Auto
|PMID=22272574
|Title=Influence of MHCIITA rs3087456 and rs4774 polymorphisms in the susceptibility to cardiovascular disease of patients with rheumatoid arthritis
}}

{{PMID Auto
|PMID=22461888
|Title=Interaction Analysis between HLA-DRB1 Shared Epitope Alleles and MHC Class II Transactivator CIITA Gene with Regard to Risk of Rheumatoid Arthritis
|OA=1
}}

{{PMID Auto
|PMID=22513452
|Title=CIITA gene variants are associated with rheumatoid arthritis in Scandinavian populations
}}

{{PMID Auto
|PMID=16318629
|Title=On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: no evidence for new predisposing factors.
|OA=1
}}

{{PMID Auto
|PMID=16920747
|Title=MHC2TA promoter polymorphism (-168*G/A, rs3087456) is not associated with susceptibility to rheumatoid arthritis in British Caucasian rheumatoid arthritis patients.
}}

{{PMID Auto
|PMID=17012290
|Title=Role of the MHC2TA gene in autoimmune diseases.
|OA=1
}}

{{PMID Auto
|PMID=17075826
|Title=Investigation of the MHC2TA gene, associated with rheumatoid arthritis in a Swedish population, in a UK rheumatoid arthritis cohort.
}}

{{PMID Auto
|PMID=17678724
|Title=Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA.
}}

{{PMID Auto
|PMID=17711409
|Title=A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus.
}}

{{PMID Auto
|PMID=17875550
|Title=The MHC2TA -168A/G polymorphism and risk for rheumatoid arthritis: a meta-analysis of 6861 patients and 9270 controls reveals no evidence for association.
|OA=1
}}

{{PMID Auto
|PMID=19063739
|Title=Genomic NGFB variation and multiple sclerosis in a case control study.
|OA=1
}}

{{PMID Auto
|PMID=19221398
|Title=Chromosomal region 16p13: further evidence of increased predisposition to immune diseases.
}}

{{PMID Auto
|PMID=20211854
|Title=CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis.
|OA=1
}}

{{PMID Auto
|PMID=21962857
|Title=Herpesvirus active replication in multiple sclerosis a genetic control?
}}

{{PMID Auto
|PMID=23133532
|Title=Polymorphisms in the Inflammatory Genes CIITA, CLEC16A and IFNG Influence BMD, Bone Loss and Fracture in Elderly Women
|OA=1
}}

{{PMID Auto
|PMID=23052709
|Title=Age-dependent variation of genotypes in MHC II transactivator gene (CIITA) in controls and association to type 1 diabetes
}}

{{PMID Auto
|PMID=23777927
|Title=Both qualitative and quantitative genetic variation of MHC class II molecules may influence susceptibility to autoimmune diseases: the case of endemic pemphigus foliaceus.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}