{{Rsnum
|rsid=3091244
|Gene=CRP
|Chromosome=1
|position=159714875
|Orientation=minus
|GMAF=0.2608
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(A;T)
|Gene_s=CRP
}}{{interesting}}

This is a [[triallelic]] SNP - note that the sidebar (currently) only shows 3 of the 6 possible genotypes.

====CRP====
{{PMID|18829218}} claims that this SNP does not affect the serum concentration of CRP, while older resources seem to disagree. However, they do report an association between CRP levels and risk of [[abdominal aortic aneurysm]] (AAA).

{{PMID|16731635}} [[rs3091244]] serum CRP level and cardiovascular risk in the NHLBI Family Heart Study. 

{{PMID|17101857}} the AA genotype of the triallelic SNP [[rs3091244]] in the gene [[CRP|C-reactive protein]] was associated with prevalent coronary [[heart disease]] in the non-Hispanic white population

{{PMID|16731635}} Association study of [[CRP]] gene polymorphisms with serum CRP level and cardiovascular risk in the NHLBI Family Heart Study. [[rs3093059]] [[rs3091244]]

{{PMID|18500540|OA=1
}} Weaker linkage disequilibrium in this region in [[African American]]s allows the conclusion that basal CRP levels are influenced in an additive manner by the T allele.

====Non CRP====

{{PMID|18055473}} increased risk for the presence of severe hand [[osteoarthritis]] with an OR of 2.3 (95% confidence interval (C.I.) 1.2-4.3, P = 0.009)

{{PMID|18182444}} [[rs3093061]] associated with [[SLE]] and functional haplotypes containing [[rs3091244]]/[[rs3093062]]  

{{ neighbor
| rsid = 3093059
| distance = 471
}}
{{ neighbor
| rsid = 3093062
| distance = 19
}}

{{PMID Auto GWAS
|PMID=18439548
|Trait=C-reactive protein
|Title=Loci Related to Metabolic-Syndrome Pathways Including LEPR, HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study
|RiskAllele=
|Pval=6.0000000000000001E-28
|OR=0.20
|ORtxt=[NR] mg/dl increase
|OA=1
}}

According to [https://www.23andme.com/you/community/thread/1144/ a 23andMe discussion] This is one of the SNPs which were re-analyzed April 2009. Customers with older data may wish to redownload. SNPs effected [[rs4420638]], [[rs34276300]], [[rs3091244]], [[rs34601266]], [[rs2033003]], [[rs7900194]], [[rs9332239]], [[rs28371685]], [[rs1229984]], and [[rs28399504]].

{{omim
|desc=STROKE, ISCHEMIC
|id=601367
|rsnum=3091244
}}

{{omim
|desc=C-REACTIVE PROTEIN, PENTRAXIN-RELATED; CRP
|id=123260
|rsnum=3091244
}}
{{PMID Auto
|PMID=19101671
|Title=Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity
}}

{{PharmGKB
|RSID=rs3091244
|Name_s=
|Gene_s=CRP, CRPP1
|Feature=Intron, Intron
|Evidence=PubMed ID:18439548
|Annotation=In a GWAS of apparantly healthy women, seven loci were found to be significantly associated with C-Reactive protein levels. 20 SNPs were significant in CRP, and this was the lead SNP.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161614205
}}

{{omim
|id=613145
|rsnum=3091244
}}

{{PMID Auto
|PMID=21413847
|Title=Polymorphism in the C-reactive protein (CRP) gene affects CRP levels in plasma and one early marker of atherosclerosis in men: The Health 2000 Survey
}}

{{PMID Auto
|PMID=21575917
|Title=C reactive protein and alpha1-antitrypsin: relationship between levels and gene variants
}}

{{PMID Auto
|PMID=21831326
|Title=CRP gene variation affects early development of Alzheimer's disease-related plaques
|OA=1
}}

{{PMID|15897982|OA=1
}} Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels.

{{PMID|16534007}} Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level.

{{PMID|16550411|OA=1
}} Allelic spectrum of the natural variation in CRP.

{{PMID|16723442|OA=1
}} A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration.

{{PMID|16832152}} Polymorphism of the C-reactive protein (CRP) gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese.

{{PMID|17161935}} Genotyping of triallelic SNPs using TaqMan PCR.

{{PMID|17900590}} C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.

{{PMID|17903293|OA=1
}} Genome-wide association with select biomarker traits in the Framingham Heart Study.

{{PMID|18162041|OA=1
}} Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.

{{PMID|18167554|OA=1
}} C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies.

{{PMID|18216863|OA=1
}} Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.

{{PMID|18285551}} Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study.

{{PMID|18394581|OA=1
}} Bayesian meta-analysis of genetic association studies with different sets of markers.

{{PMID|18704199|OA=1
}} Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration.

{{PMID|18714384|OA=1
}} The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants.

{{PMID|18793001|OA=1
}} Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations.

{{PMID|18852197|OA=1
}} Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.

{{PMID|19076828|OA=1
}} Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study.

{{PMID|19095725|OA=1
}} Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort.

{{PMID|19262552}} C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population.

{{PMID|19272152|OA=1
}} IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

{{PMID|19336475|OA=1
}} Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.

{{PMID|19410251}} Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults.

{{PMID|19426506|OA=1
}} C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery.

{{PMID|19436291|OA=1
}} C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk.

{{PMID|19545442|OA=1
}} Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa.

{{PMID|19567438|OA=1
}} Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.

{{PMID|19946607|OA=1
}} Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria.

{{PMID|20031577|OA=1
}} Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.

{{PMID|20494378}} Association between functional variants of the ICAM1 and CRP genes and metabolic syndrome in Taiwanese subjects.

{{PMID|20616999|OA=1
}} Usefulness of Mendelian randomization in observational epidemiology.

{{PMID|20714329}} C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization.

{{PMID|21034294}} C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects.

{{PMID|21496483}} Fatigued breast cancer survivors and gene polymorphisms in the inflammatory pathway.

{{PMID|21647738|OA=1
}} Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.

{{PMID|21773944}} Lack of association between the genetic variations in the C-reactive protein gene and the risk of psoriasis among the Taiwanese.

{{PMID|21979869|OA=1
}} C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3091244
|overall_frequency_n=53
|overall_frequency_d=128
|overall_frequency=0.414062
|n_genomes=32
|n_genomes_annotated=0
|n_haplomes=37
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22875596
|Title=Association study of CRP gene and ischemic stroke in a Chinese Han population
}}

{{PMID Auto
|PMID=23940726
|Title=Two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an american Indian population
|OA=1
}}

{{PMID Auto
|PMID=24135623
|Title=C-reactive protein polymorphism rs3091244 is associated with abdominal aortic aneurysm
}}

{{PMID Auto
|PMID=24762112
|Title=Increased body mass index, elevated C-reactive protein, and short telomere length
}}

{{PMID Auto
|PMID=25025473
|Title=Mutations of C-Reactive Protein (CRP) -286 SNP, APC and p53 in Colorectal Cancer: Implication for a CRP-Wnt Crosstalk
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}