{{Rsnum
|rsid=3095870
|Gene=NKX2-5
|Chromosome=5
|position=173236451
|Orientation=minus
|GMAF=0.2328
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=NKX2-5
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 13.3 | 46.0 | 40.7
| HCB | 0.0 | 10.2 | 89.8
| JPT | 0.9 | 15.9 | 83.2
| YRI | 6.1 | 29.3 | 64.6
| ASW | 10.5 | 35.1 | 54.4
| CHB | 0.0 | 10.2 | 89.8
| CHD | 0.0 | 11.0 | 89.0
| GIH | 19.8 | 39.6 | 40.6
| LWK | 0.9 | 33.6 | 65.5
| MEX | 3.4 | 53.4 | 43.1
| MKK | 0.0 | 35.3 | 64.7
| TSI | 11.8 | 46.1 | 42.2
| HapMapRevision=28
}}[[rs3095870]] is a SNP in the promoter region of the [[NKX2.5]] gene; it is also known as -1192C>T.

[[rs3095870]] has been linked to increased risk for systemic lupus erythematosus ([[SLE]]) in two independent Japanese case-control samples (p=0.0037 with odds ratio of 1.74, CI:1.19-2.55). Individuals with risk genotypes of both [[rs3748079]] and [[rs3095870]], in the [[ITPR3]] and [[NKX2.5]] genes, respectively, have even high risk for [[SLE]] (odds ratio 5.77, CI: 3.17-10.1).{{PMID|18219441}}

Note that the orientation of this SNP as published is reversed compared to the dbSNP entry.

{{omim
|desc=SYSTEMIC LUPUS ERYTHEMATOSUS; SLE
|id=152700
|rsnum=3095870
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}