{{Rsnum
|rsid=3130340
|Chromosome=6
|position=32276850
|Orientation=plus
|GMAF=0.2498
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 2.7 | 36.3 | 61.1
| HCB | 3.7 | 34.6 | 61.8
| JPT | 6.2 | 31.0 | 62.8
| YRI | 14.4 | 47.3 | 38.4
| ASW | 8.8 | 47.4 | 43.9
| CHB | 3.7 | 34.6 | 61.8
| CHD | 4.6 | 33.3 | 62.0
| GIH | 7.0 | 38.0 | 55.0
| LWK | 14.5 | 51.8 | 33.6
| MEX | 1.8 | 21.1 | 77.2
| MKK | 10.3 | 41.9 | 47.7
| TSI | 4.9 | 30.4 | 64.7
| HapMapRevision=28
}}

rs3130340 increases susceptibility to Bone mineral density variations, lower for carriers of the T allele {{PMID|18445777}}

rs3130340 increases susceptibility to Osteoporotic fractures for carriers of the T allele {{PMID|18445777}}

{{GWAS Summary
|SNP=rs3130340
|PubMedID=18445777
|Condition=Bone mineral density (spine)
|Gene=MHC, C6orf10
|Risk Allele=T
|pValue=1.00E-007
|OR=0.1
|95CI=0.06-0.13) SD decreas
}}

{{PharmGKB
|RSID=rs3130340
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18445777; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Multiple Genetic Loci for Bone Mineral Density and Fractures (Initial Sample Size: 5,861 individuals; Replication Sample Size: 7,925 individuals; Risk Allele: rs3130340-T). This variant is associated with Bone mineral density (spine).
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases; Bone Diseases, Metabolic; Fractures, Bone
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356556
}}

{{PMID Auto
|PMID=21646926
|Title=Interactions of osteoporosis candidate genes for age at menarche, age at natural menopause, and maximal height in Han Chinese women
}}

{{PMID Auto
|PMID=22370887
|Title=Are bone mineral density loci associated with hip osteoporotic fractures? A validation study on previously reported genome-wide association loci in a Chinese population
|OA=1
}}

{{PMID Auto
|PMID=19181680
|Title=Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.
|OA=1
}}

{{PMID Auto
|PMID=20018075
|Title=Genome-wide association study of rheumatoid arthritis by a score test based on wavelet transformation.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3130340
|overall_frequency_n=26
|overall_frequency_d=128
|overall_frequency=0.203125
|n_genomes=19
|n_genomes_annotated=0
|n_haplomes=21
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}