{{Rsnum
|rsid=3131296
|Gene=NOTCH4
|Chromosome=6
|position=32205216
|Orientation=minus
|GMAF=0.06887
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=NOTCH4
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 17.0 | 83.0
| HCB | 1.5 | 8.8 | 89.8
| JPT | 0.0 | 3.7 | 96.3
| YRI | 0.0 | 4.2 | 95.8
| ASW | 0.0 | 17.9 | 82.1
| CHB | 1.5 | 8.8 | 89.8
| CHD | 0.0 | 7.4 | 92.6
| GIH | 2.0 | 13.9 | 84.2
| LWK | 0.0 | 18.2 | 81.8
| MEX | 0.0 | 14.0 | 86.0
| MKK | 0.0 | 11.7 | 88.3
| TSI | 0.0 | 23.8 | 76.2
| HapMapRevision=28
}}[http://blog.23andme.com/2009/07/03/snpwatch-researchers-show-importance-of-common-dna-variants-in-schizophrenia/ 23andMe blog] [[schizophrenia]]
*[[rs3131296]](C) increased the odds of schizophrenia by 1.19x
*[[rs12807809]](T) increased the odds of schizophrenia by 1.15x
*[[rs9960767]](C) increased the odds of schizophrenia by 1.23 times.

{{PMID|20673877}} A study of ~2,500 Han Chinese patients with [[schizophrenia]] did find [[rs3131296]] to be significantly associated in this population.

{{PMID Auto GWAS
|PMID=19571808
|Trait=Schizophrenia
|Title=Common variants conferring risk of schizophrenia
|RiskAllele=G
|Pval=2E-10
|OR=1.19
|ORtxt=[NR]
|OA=1
}}

{{PMID Auto
|PMID=18204098
|Title=Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
}}

{{PMID Auto
|PMID=19343178
|Title=Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.
|OA=1
}}

{{PMID Auto
|PMID=23053058
|Title=Search for schizophrenia susceptibility variants at the HLA-DRB1 locus among a British population
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3131296
|overall_frequency_n=14
|overall_frequency_d=128
|overall_frequency=0.109375
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=13
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22005930
|Title=Genome-wide association study of Alzheimer's disease with psychotic symptoms.
|OA=1
}}

{{PMID Auto
|PMID=25142293
|Title=Association between the NOTCH4 gene rs3131296 polymorphism with schizophrenia risk in the Chinese Zhuang population and Chinese Han population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}