{{Rsnum
|rsid=3131379
|Gene=MSH5
|Chromosome=6
|position=31753256
|Orientation=minus
|GMAF=0.04408
|Gene_s=MSH5,MSH5-SAPCD1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 85.0 | 14.2 | 0.9
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 85.0 | 14.3 | 0.7
| ASW | 91.2 | 8.8 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 95.5 | 4.5 | 0.0
| MEX | 93.1 | 6.9 | 0.0
| MKK | 90.4 | 9.6 | 0.0
| TSI | 87.3 | 12.7 | 0.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=18204446
|Trait=Systemic lupus erythematosus in women
|Title=Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
|RiskAllele=A
|Pval=2E-52
|OR=2.36
|ORtxt=[2.11-2.64]
|OA=1
}}

{{omim
|desc=LUNG CANCER SUSCEPTIBILITY 4; LNCR4
|id=612593
|rsnum=3131379
}}

{{PMID Auto
|PMID=22382497
|Title=Lung Cancer and DNA Repair Genes: Multilevel Association Analysis from the International Lung Cancer Consortium
|OA=1
}}

{{PMID Auto
|PMID=18978787
|Title=Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19197363
|Title=A genome-wide investigation of SNPs and CNVs in schizophrenia.
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=19849816
|Title=Genetics of rheumatic disease.
|OA=1
}}

{{PMID Auto
|PMID=20017995
|Title=A principal-components-based clustering method to identify multiple variants associated with rheumatoid arthritis and arthritis-related autoantibodies.
|OA=1
}}

{{PMID Auto
|PMID=20805886
|Title=Unique DNA repair gene variations and potential associations with the primary antibody deficiency syndromes IgAD and CVID.
|OA=1
}}

{{PMID Auto
|PMID=21952918
|Title=Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3131379
|overall_frequency_n=1002
|overall_frequency_d=10758
|overall_frequency=0.09314
|n_genomes=6
|n_genomes_annotated=0
|n_haplomes=6
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}