{{Rsnum
|rsid=314276
|Gene=LIN28B
|Chromosome=6
|position=104960124
|Orientation=plus
|GMAF=0.3641
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=LIN28B
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 7.1 | 57.5 | 35.4
| HCB | 8.9 | 37.8 | 53.3
| JPT | 1.8 | 49.1 | 49.1
| YRI | 16.7 | 50.0 | 33.3
| ASW | 19.3 | 52.6 | 28.1
| CHB | 8.9 | 37.8 | 53.3
| CHD | 7.5 | 47.7 | 44.9
| GIH | 11.1 | 47.5 | 41.4
| LWK | 19.1 | 60.0 | 20.9
| MEX | 5.3 | 43.9 | 50.9
| MKK | 20.6 | 46.5 | 32.9
| TSI | 10.3 | 45.4 | 44.3
| HapMapRevision=28
}}[http://blog.23andme.com/2009/05/18/snpwatch-researchers-link-common-genetic-variations-to-those-changes-a-womans-body-goes-through/ 23andMe blog]
[[rs314276]] or the equivalent [[rs314263]](T) yields
*Female
**[[menarche]] about six weeks earlier
**1.2x accelerated breast development and a faster rate of increase in height and weight.
**a reduction in adult [[height]] of about 0.15 inches.
*Male
**1.26 greater odds of advanced voice breaking at age 15
**1.19 times greater odds of advanced pubic hair at age 13
**faster rate of growth at age 10 and about a tenth of an inch less in adult [[height]].

{{PMID Auto GWAS
|PMID=19448623
|Trait=Menarche (age at onset)
|Title=Genetic variation in LIN28B is associated with the timing of puberty
|RiskAllele=C
|Pval=4E-16
|OR=0.14
|ORtxt=[0.11-0.17] years younger
|OA=1
}}

{{omim
|id=612882
|rsnum=314276
}}

{{PMID Auto
|PMID=20962026
|Title=Associations between the Pubertal Timing-Related Variant in LIN28B and BMI Vary Across the Life Course
|OA=1
}}

{{PMID Auto
|PMID=22822098
|Title=Functional Study of Risk Loci of Stem Cell-associated Gene Lin-28B and Associations with Disease Survival Outcomes in Epithelial Ovarian Cancer
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs314276
|overall_frequency_n=59
|overall_frequency_d=92
|overall_frequency=0.641304
|n_genomes=32
|n_genomes_annotated=0
|n_haplomes=49
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}