{{Rsnum
|rsid=316019
|Gene=SLC22A2
|Chromosome=6
|position=160249250
|Orientation=minus
|GMAF=0.1221
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=SLC22A2
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 81.4 | 17.7 | 0.9
| HCB | 77.9 | 21.3 | 0.7
| JPT | 76.6 | 22.5 | 0.9
| YRI | 72.4 | 24.8 | 2.8
| ASW | 70.2 | 28.1 | 1.8
| CHB | 77.9 | 21.3 | 0.7
| CHD | 79.8 | 18.3 | 1.8
| GIH | 71.0 | 28.0 | 1.0
| LWK | 73.1 | 25.9 | 0.9
| MEX | 84.5 | 15.5 | 0.0
| MKK | 75.5 | 21.9 | 2.6
| TSI | 77.2 | 20.8 | 2.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs316019
|Name_s=SLC22A2: A270S
|Gene_s=SLC22A2
|Feature=Exon/NonSyn
|Evidence=PubMed ID:19940846
|Annotation=Increased metformin uptake in transfected cells
|Drugs=metformin
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA165111567
}}

{{PharmGKB
|RSID=rs316019
|Name_s=SLC22A2: Ala270Ser
|Gene_s=SLC22A2
|Feature=Exon/NonSyn
|Evidence=PubMed ID:19625999
|Annotation=This study found that this nonsynonymous SNP in the SLC22A2 gene was associated with reduced cisplatin-induced nephrotoxicity in patients.
|Drugs=cisplatin
|Drug Classes=
|Diseases=nephrotoxicity
|Curation Level=Curated
|PharmGKB Accession ID=PA164934776
}}

{{PharmGKB
|RSID=rs316019
|Name_s=SLC22A2: A270S
|Gene_s=SLC22A2
|Feature=Exon/NonSyn
|Evidence=PubMed ID:19940846
|Annotation=Higher renal clearance and net tubular secretion of metformin in individuals with this variant
|Drugs=metformin
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA165111610
}}

{{PMID Auto
|PMID=18559608
|Title=Interaction of Cisplatin with the human organic cation transporter 2.
}}

{{PMID Auto
|PMID=20429798
|Title=Association of the SLC22A1, SLC22A2, and SLC22A3 genes encoding organic cation transporters with diabetic nephropathy and hypertension.
}}

{{GET Evidence
|gene=SLC22A2
|aa_change=Ser270Ala
|aa_change_short=S270A
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs316019
|overall_frequency_n=9481
|overall_frequency_d=10758
|overall_frequency=0.881298
|n_genomes=56
|n_genomes_annotated=0
|n_haplomes=101
|n_articles=2
|n_articles_annotated=2
|in_pharmgkb=Y
|nblosum100=-1
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22882994
|Title=Pharmacogenomic association between a variant in SLC47A1 gene and therapeutic response to metformin in type 2 diabetes.
}}

{{PMID Auto
|PMID=25143296
|Title=Organic Cation Transporter Variation and Response to Smoking Cessation Therapies
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}