{{Rsnum
|rsid=3173615
|Gene=TMEM106B
|Chromosome=7
|position=12229791
|Orientation=plus
|GMAF=0.4513
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=TMEM106B
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 40.6 | 50.0 | 9.4
| HCB | 15.6 | 31.1 | 53.3
| JPT | 18.2 | 47.7 | 34.1
| YRI | 1.6 | 34.9 | 63.5
| ASW | 0.0 | 0.0 | 0.0
| CHB | 15.6 | 31.1 | 53.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=21220649
|Title=Association of TMEM106B Gene Polymorphism With Age at Onset in Granulin Mutation Carriers and Plasma Granulin Protein Levels
|OA=1
}}

{{PMID Auto
|PMID=21354975
|Title=TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort.
|OA=1
}}

{{GET Evidence
|gene=TMEM106B
|aa_change=Thr185Ser
|aa_change_short=T185S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3173615
|overall_frequency_n=5348
|overall_frequency_d=10754
|overall_frequency=0.497303
|n_genomes=46
|n_genomes_annotated=0
|n_haplomes=68
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.418
|nblosum100=-2
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23742080
|Title=TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia
}}

{{PMID Auto
|PMID=24385136
|Title=TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia
}}

{{on chip | HumanOmni1Quad}}