{{Rsnum
|rsid=317689
|Chromosome=12
|position=69333410
|Orientation=plus
|GMAF=0.23
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 55.8 | 38.9 | 5.3
| HCB | 59.9 | 31.4 | 8.8
| JPT | 47.3 | 46.4 | 6.2
| YRI | 85.0 | 14.3 | 0.7
| ASW | 70.2 | 28.1 | 1.8
| CHB | 59.9 | 31.4 | 8.8
| CHD | 61.1 | 32.4 | 6.5
| GIH | 54.5 | 42.6 | 3.0
| LWK | 71.8 | 26.4 | 1.8
| MEX | 55.2 | 41.4 | 3.4
| MKK | 76.3 | 21.2 | 2.6
| TSI | 47.1 | 45.1 | 7.8
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs317689,rs315135,rs7297610
|PubMedID=18591461
|Condition=Response to diuretic therapy
|Gene=LYZ, YEATS4, FRS2
|Risk Allele=e
|pValue=6.00E-006
|OR=NA
|95CI=
|OA=1
}}

{{PharmGKB
|RSID=rs317689
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18591461; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic (Initial Sample Size: 194 blacks, 195 whites; Replication Sample Size: NR). This variant is associated with Response to diuretic therapy.
|Drugs=hydrochlorothiazide
|Drug Classes=THIAZIDE DERIVATIVES
|Diseases=Hypertension
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356543
}}

{{PMID Auto
|PMID=22350108
|Title=Association of chromosome 12 locus with antihypertensive response to hydrochlorothiazide may involve differential YEATS4 expression.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs317689
|overall_frequency_n=102
|overall_frequency_d=126
|overall_frequency=0.809524
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=92
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}