{{Rsnum
|rsid=3194051
|Gene=IL7R
|Chromosome=5
|position=35876172
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.2254
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=IL7R
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 46.9 | 42.5 | 10.6
| HCB | 89.8 | 10.2 | 0.0
| JPT | 90.3 | 8.8 | 0.9
| YRI | 35.6 | 47.9 | 16.4
| ASW | 52.6 | 40.4 | 7.0
| CHB | 89.8 | 10.2 | 0.0
| CHD | 90.8 | 9.2 | 0.0
| GIH | 65.3 | 29.7 | 5.0
| LWK | 54.5 | 38.2 | 7.3
| MEX | 67.2 | 32.8 | 0.0
| MKK | 66.0 | 30.8 | 3.2
| TSI | 51.0 | 38.2 | 10.8
| HapMapRevision=28
}}[[rs3194051]], one of several SNPs in the [[IL7R]] gene, has been reported in a large study to be associated with [[type-1 diabetes]].

In an expanded follow-up study of >6,000 controls and 6,000 patients, the heterozygote odds ratio for this SNP was recalculated to be 1.12 (CI 1.05â€“1.19). {{PMID|17554260|OA=1
}}

{{ neighbor
| rsid = 987106
| distance = 681
}}

{{PharmGKB
|RSID=rs3194051
|Name_s=
|Gene_s=IL7R
|Feature=
|Evidence=PubMed ID:17660816
|Annotation=In a case-control study of Nordic populations, rs3194051 was associated with risk of multiple sclerosis.
|Drugs=
|Drug Classes=
|Diseases=Multiple Sclerosis
|Curation Level=Curated
|PharmGKB Accession ID=PA162356127
}}

{{PharmGKB
|RSID=rs3194051
|Name_s=
|Gene_s=IL7R
|Feature=
|Evidence=PubMed ID:17660816
|Annotation=In a nordic case-control group consisted of 1,820 individuals with multiple sclerosis and 2,634 healthy controls this SNP in exon 8 of the IL7R gene confirmed association with multiple sclerosis.
|Drugs=
|Drug Classes=
|Diseases=Multiple Sclerosis
|Curation Level=Curated
|PharmGKB Accession ID=PA162355788
}}

{{PMID Auto GWAS
|PMID=21297633
|Trait=None
|Title=Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
|RiskAllele=G
|Pval=4E-8
|OR=1.0700
|ORtxt=[1.02-1.12]
|OA=1
}}

{{PMID|18563381}} Study of the association between the CAPSL-IL7R locus and type 1 diabetes.

{{PMID|19221116|OA=1
}} Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS.

{{PMID|19359276|OA=1
}} Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.

{{PMID|19956108|OA=1
}} Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.

{{GET Evidence
|gene=IL7R
|aa_change=Ile356Val
|aa_change_short=I356V
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3194051
|overall_frequency_n=3167
|overall_frequency_d=10758
|overall_frequency=0.294386
|n_genomes=24
|n_genomes_annotated=0
|n_haplomes=28
|n_articles=1
|n_articles_annotated=1
|gene_in_genetests=Y
|in_pharmgkb=Y
|genetests_testable=Y
|nblosum100=-4
|autoscore=3
|webscore=N
|n_web_uneval=5
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}