{{Rsnum
|rsid=3200254
|Gene=ALPL
|Chromosome=1
|position=21568242
|Orientation=plus
|GMAF=0.2787
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ALPL
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 2.7 | 20.4 | 77.0
| HCB | 18.4 | 52.2 | 29.4
| JPT | 30.6 | 53.2 | 16.2
| YRI | 11.6 | 39.7 | 48.6
| ASW | 5.3 | 40.4 | 54.4
| CHB | 18.4 | 52.2 | 29.4
| CHD | 27.5 | 46.8 | 25.7
| GIH | 5.9 | 27.7 | 66.3
| LWK | 7.3 | 34.5 | 58.2
| MEX | 12.1 | 36.2 | 51.7
| MKK | 2.6 | 28.2 | 69.2
| TSI | 0.0 | 20.6 | 79.4
| HapMapRevision=28
}}{{PMID|17195227}} Association of a TNAP haplotype with ankylosing spondylitis.

{{PMID|18769922}} No significant association between genetic polymorphisms in the TNAP gene and ankylosing spondylitis in the Chinese Han population.

{{PMID|19500388|OA=1
}} Mild forms of hypophosphatasia mostly result from dominant negative effect of severe alleles or from compound heterozygosity for severe and moderate alleles.{{GET Evidence
|gene=ALPL
|aa_change=Tyr263His
|aa_change_short=Y263H
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3200254
|overall_frequency_n=1757
|overall_frequency_d=10758
|overall_frequency=0.16332
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=24
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=-1
|autoscore=3
|n_web_uneval=3
}}