{{Rsnum
|rsid=3212227
|Gene=IL12B
|Chromosome=5
|position=159315942
|Orientation=minus
|GMAF=0.3384
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=IL12B
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 62.8 | 36.3 | 0.9
| HCB | 30.7 | 54.7 | 14.6
| JPT | 23.9 | 45.1 | 31.0
| YRI | 42.9 | 43.5 | 13.6
| ASW | 50.9 | 36.8 | 12.3
| CHB | 30.7 | 54.7 | 14.6
| CHD | 32.4 | 46.3 | 21.3
| GIH | 47.5 | 39.6 | 12.9
| LWK | 33.6 | 48.2 | 18.2
| MEX | 43.1 | 37.9 | 19.0
| MKK | 47.4 | 46.2 | 6.4
| TSI | 55.9 | 36.3 | 7.8
| HapMapRevision=28
}}IL12B gene SNP, part of a haplotype with [[rs6887695]] associated with [[psoriasis]].{{PMID|18219280|OA=1
}}

A study of 500+ patients with [[psoriatic arthritis]] (PsA) concluded that the odds ratio for [[rs3212227]](A;A) carriers was 1.43 (CI: 1.17-1.76). The effect sizes observed in patients with PsA appear to be smaller than those previously reported in patients with psoriasis, suggesting that both loci are primarily associated with [[psoriasis]] susceptibility rather than primarily with [[psoriatic arthritis]].{{PMID|19035472|OA=1
}}

{{PMID|19118071}} [[rs568408]] GA/AA and [[rs3212227]] AC/CC variant genotypes were associated with a significantly increased risk of [[cervical cancer]] [adjusted odds ratio, 1.43; 95% confidence interval (CI), 1.06-1.93; and adjusted odds ratio, 1.30; 95% CI, 0.97-1.75, respectively]. subjects carrying variant genotypes of both loci had a 1.82-fold (95% CI, 1.28-2.57) increased risk of cervical cancer

{{ neighbor
| rsid = 3213119
| distance = 838
}}

{{PMID Auto
|PMID=19956104
|Title=Evaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics Consortium
|OA=1
}}

{{PMID Auto
|PMID=19705136
|Title=Genetic evidence for involvement of the IL23 pathway in Thai psoriatics
|OA=1
}}

{{PMID Auto
|PMID=20387064
|Title=Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults
|OA=1
}}

{{PMID Auto
|PMID=21339808
|Title=Interleukin 12B (IL12B) Genetic Variation and Pulmonary Tuberculosis: A Study of Cohorts from The Gambia, Guinea-Bissau, United States and Argentina
|OA=1
}}
{{omim
|id=605606
|rsnum=3212227
}}

{{omim
|id=607507
|rsnum=3212227
}}

{{omim
|id=612599
|rsnum=3212227
}}

{{PMID Auto
|PMID=21513752
|Title=Association of single nucleotide polymorphisms in interleukin 12 (IL-12A and -B) with asthma in a Chinese population
}}

{{PMID Auto
|PMID=22011063
|Title=Gene-Gene Interactions Between Interleukin-12A and Interleukin-12B with the Risk of Brain Tumor
}}

{{PMID Auto
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|Title=Association of IL-12B Genetic Polymorphism with the Susceptibility and Disease Severity of Ankylosing Spondylitis
}}

{{PMID Auto
|PMID=22581790
|Title=Effect of IL12A and IL12B polymorphisms on the risk of Chlamydia trachomatis-induced tubal factor infertility and disease severity
|OA=1
}}

{{PMID Auto
|PMID=22702905
|Title=Single Nucleotide Polymorphism in the Interleukin 12B Gene is Associated With Risk for Breast Cancer Development
}}

{{PMID Auto
|PMID=22734699
|Title=Association Between Single-Nucleotide Polymorphisms in Interleukin-12A and Risk of Chronic Obstructive Pulmonary Disease
|OA=1
}}

{{PMID Auto
|PMID=22739501
|Title=Resequencing of the IL12B gene in psoriasis patients with the rs6887695/rs3212227 risk genotypes
}}

{{PMID Auto
|PMID=22788685
|Title=Polymorphisms of pro-inflammatory cytokine genes and the risk for acute suppurative or chronic nonsuppurative apical periodontitis in a Colombian population
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
|PMID=16600026
|Title=Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.
|OA=1
}}

{{PMID Auto
|PMID=16759385
|Title=Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA).
|OA=1
}}

{{PMID Auto
|PMID=17236132
|Title=A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.
|OA=1
}}

{{PMID Auto
|PMID=17327408
|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=17587057
|Title=Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis.
}}

{{PMID Auto
|PMID=17901940
|Title=Association analysis of IL-12B and IL-23R polymorphisms in myocardial infarction.
}}

{{PMID Auto
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|Title=The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18369459
|Title=A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.
|OA=1
}}

{{PMID Auto
|PMID=18383521
|Title=IL23R and IL12B polymorphisms in Spanish IBD patients: no evidence of interaction.
}}

{{PMID Auto
|PMID=18609743
|Title=Genetics of psoriasis and psoriatic arthritis: update and future direction.
|OA=1
}}

{{PMID Auto
|PMID=18633131
|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
|PMID=18800148
|Title=Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis.
}}

{{PMID Auto
|PMID=19066394
|Title=Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19182814
|Title=New insights into the pathogenesis and genetics of psoriatic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19230157
|Title=Immunogenetics of seasonal influenza vaccine response.
|OA=1
}}

{{PMID Auto
|PMID=19235914
|Title=Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=19356949
|Title=Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
|OA=1
}}

{{PMID Auto
|PMID=19956101
|Title=Overview of the Rapid Response data.
|OA=1
}}

{{PMID Auto
|PMID=19956106
|Title=Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.
|OA=1
}}

{{PMID Auto
|PMID=19956109
|Title=The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.
|OA=1
}}

{{PMID Auto
|PMID=20350312
|Title=Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya.
|OA=1
}}

{{PMID Auto
|PMID=20521253
|Title=IL12 polymorphisms, HBV infection and risk of hepatocellular carcinoma in a high-risk Chinese population.
}}

{{PMID Auto
|PMID=20525402
|Title=Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.
|OA=1
}}

{{PMID Auto
|PMID=20544370
|Title=Association of genetic polymorphisms in the IL12-IFNG pathway with susceptibility to and prognosis of pulmonary tuberculosis in a Chinese population.
}}

{{PMID Auto
|PMID=20606885
|Title=Genetics of psoriasis and psoriatic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{PMID Auto
|PMID=20818961
|Title=Inflammatory mediators gene polymorphisms in preeclampsia.
}}

{{PMID Auto
|PMID=21198744
|Title=The clinical presentation of autoimmune thyroid disease in men is associated with IL12B genotype.
}}

{{PMID Auto
|PMID=21875636
|Title=Associations between single nucleotide polymorphisms and haplotypes in cytokine and cytokine receptor genes and immunity to measles vaccination.
|OA=1
}}

{{PMID Auto
|PMID=22372709
|Title=Cytokine gene polymorphisms in the susceptibility to acute coronary syndrome.
}}

{{PMID Auto
|PMID=22515181
|Title=Interleukin-12: clinical usage and molecular markers of cancer susceptibility.
}}

{{PMID Auto
|PMID=22614250
|Title=Contribution of IL12A and IL12B Polymorphisms to the Risk of Cervical Cancer.
}}

{{PMID Auto
|PMID=23578145
|Title=Levels of interleukin-(IL)-12p40 are markedly increased in brucellosis among patients with specific IL-12B genotypes
}}

{{PMID Auto
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|Title=Interleukin 10 rs1800872 T&gt;G Polymorphism was Associated with an Increased Risk of Esophageal Cancer in a Chinese Population
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{{PMID Auto
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}}

{{PMID Auto
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|Title=Meta-analysis of IL12B polymorphisms (rs3212227, rs6887695) with psoriasis and psoriatic arthritis
}}

{{PMID Auto
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|Title=Associations between polymorphisms in IL-12A, IL-12B, IL-12Rbeta1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer.
}}

{{PMID Auto
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}}

{{PMID Auto
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|Title=Functional polymorphisms in the interleukin-12 gene contribute to cancer risk: evidence from a meta-analysis of 18 case-control studies.
}}

{{PMID Auto
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|OA=1
}}

{{PMID Auto
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|Title=Interleukin-12B rs3212227 polymorphism and cancer risk: a meta-analysis.
}}

{{PMID Auto
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|Title=Interactions of interleukin-12A and interleukin-12B polymorphisms on the risk of intracranial aneurysm.
}}

{{PMID Auto
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|Title=Gene-gene interaction and functional impact of polymorphisms on innate immune genes in controlling Plasmodium falciparum blood infection level.
|OA=1
}}

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|Title=Interleukin-12B gene polymorphism frequencies in Egyptians and sex-related susceptibility to hepatitis C infection.
}}

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|Title=Genetic Variations of IL-12B, IL-12Rβ1, IL-12Rβ2 in Behcet's Disease and VKH Syndrome
}}

{{PMID Auto
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|Title=Genetic variation at IL12B, IL23R and IL23A is associated with psoriasis severity, psoriatic arthritis and type 2 diabetes mellitus
}}

{{PMID Auto
|PMID=25037175
|Title=Association of IL-12A and IL-12B polymorphisms with Alzheimer's disease susceptibility in a Han Chinese population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}