{{Rsnum
|rsid=3213619
|Gene=ABCB1
|Chromosome=7
|position=87600877
|Orientation=minus
|GMAF=0.06015
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ABCB1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 6.2 | 93.8
| HCB | 0.7 | 13.9 | 85.4
| JPT | 0.0 | 11.5 | 88.5
| YRI | 0.0 | 12.2 | 87.8
| ASW | 0.0 | 12.3 | 87.7
| CHB | 0.7 | 13.9 | 85.4
| CHD | 0.0 | 6.4 | 93.6
| GIH | 0.0 | 8.9 | 91.1
| LWK | 0.9 | 21.8 | 77.3
| MEX | 0.0 | 3.4 | 96.6
| MKK | 3.2 | 19.9 | 76.9
| TSI | 1.0 | 4.9 | 94.1
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs3213619
|Name_s=ABCB1:T-129C
|Gene_s=ABCB1
|Feature=5' UTR
|Evidence=PubMed ID:16819187; PubMed ID:16906020; PubMed ID:17548681; PubMed ID:17635180; PubMed ID:19285054
|Annotation=This variant is in exon 1b of ABCB1 and may be associated with tacrolimus pharmacokinetics in renal transplant recipients. It was also associated with lower ABCB1 mRNA expression and possibly being an useful invasive marker predicting poorly-differentiated colorectal adenocarcinomas and thereby the poor prognosis of the Japanese patients in the study.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA164738437
}}

{{PMID Auto
|PMID=17146660
|Title=Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers.
}}

{{PMID Auto
|PMID=17622943
|Title=Comparative and evolutionary pharmacogenetics of ABCB1: complex signatures of positive selection on coding and regulatory regions.
}}

{{PMID Auto
|PMID=18424454
|Title=ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence.
|OA=1
}}

{{PMID Auto
|PMID=20354687
|Title=Explaining variability in ciclosporin exposure in adult kidney transplant recipients.
|OA=1
}}

{{PMID Auto
|PMID=20389299
|Title=Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.
|OA=1
}}

{{PMID Auto
|PMID=22306099
|Title=Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3213619
|overall_frequency_n=5
|overall_frequency_d=128
|overall_frequency=0.0390625
|n_genomes=4
|n_genomes_annotated=0
|n_haplomes=4
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24572589
|Title=Novel and functional ABCB1 gene variant in sporadic Parkinson's disease
}}

{{PMID Auto
|PMID=24599932
|Title=Replication of Genetic Polymorphisms Reported to be Associated with Taxane-Related Sensory Neuropathy in Early Breast Cancer Patients treated with Paclitaxel
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}