{{Rsnum
|rsid=3218536
|Gene=XRCC2
|Chromosome=7
|position=152648922
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.0427
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=XRCC2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.9 | 17.7 | 81.4
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 10.5 | 89.5
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 1.0 | 20.8 | 78.2
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 10.3 | 89.7
| MKK | 0.0 | 7.1 | 92.9
| TSI | 0.0 | 20.6 | 79.4
| HapMapRevision=28
}}
[[rs3218536]], a relatively rare SNP also known as Arg188His located in the DNA-repair gene [[XRCC2]], is associated with a lowered risk for [[breast cancer]] based on a study of 1,100 Cypriot women. The odds ratio for the His-encoding [[rs3218536]](A) allele carriers is homozygote is 0.79, CI: 0.62-1.00, p=0.05.{{PMID|18188695}}

[[rs3218536]](A) carriers also appear to be at lower risk for epithelial [[ovarian cancer]]. In a study of ~1,600 cases, the odds ratio for [[rs3218536]](A;G) heterozygotes was 0.8 (CI: 0.7-1.0) and for the (quite rare) [[rs3218536]](A;A) homozygotes 0.3 (0.1-0.9).{{PMID|15924337}}

{{PMID Auto
|PMID=19690184
|Title=Genetic Variants in XRCC2: New Insights Into Colorectal Cancer Tumorigenesis
|OA=1
}}

{{PMID Auto
|PMID=20127279
|Title=XRCC2 Arg188His polymorphism is not directly associated with breast cancer risk: evidence from 37,369 subjects
}}

{{PMID Auto
|PMID=21632523
|Title=A role for XRCC2 gene polymorphisms in breast cancer risk and survival
|OA=1
}}

{{PMID Auto
|PMID=22481871
|Title=Assessment of genetic mutations in the XRCC2 coding region by high resolution melting curve analysis and the risk of differentiated thyroid carcinoma in Iran
|OA=1
}}

{{PMID Auto
|PMID=16465622
|Title=Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.
|OA=1
}}

{{PMID Auto
|PMID=16857995
|Title=Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes.
|OA=1
}}

{{PMID Auto
|PMID=17557904
|Title=Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk.
}}

{{PMID Auto
|PMID=18086758
|Title=Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set.
|OA=1
}}

{{PMID Auto
|PMID=18191955
|Title=Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.
|OA=1
}}

{{PMID Auto
|PMID=18768505
|Title=Genetic susceptibility to renal cell carcinoma: the role of DNA double-strand break repair pathway.
|OA=1
}}

{{PMID Auto
|PMID=18990748
|Title=International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.
|OA=1
}}

{{PMID Auto
|PMID=19064565
|Title=Common single-nucleotide polymorphisms in DNA double-strand break repair genes and breast cancer risk.
}}

{{PMID Auto
|PMID=19124506
|Title=Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=19127255
|Title=Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium.
|OA=1
}}

{{PMID Auto
|PMID=19276285
|Title=Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=19367277
|Title=Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=19543528
|Title=Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer.
|OA=1
}}

{{PMID Auto
|PMID=20004634
|Title=Breast cancer risk and common single nucleotide polymorphisms in homologous recombination DNA repair pathway genes XRCC2, XRCC3, NBS1 and RAD51.
}}

{{PMID Auto
|PMID=21104022
|Title=Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer--a case control study.
|OA=1
}}

{{PMID Auto
|PMID=21974800
|Title=DNA repair gene polymorphisms and risk of early onset colorectal cancer in Lynch syndrome.
}}

{{GET Evidence
|gene=XRCC2
|aa_change=Arg188His
|aa_change_short=R188H
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3218536
|overall_frequency_n=605
|overall_frequency_d=10758
|overall_frequency=0.0562372
|n_genomes=6
|n_genomes_annotated=0
|n_haplomes=6
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.006
|nblosum100=1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23539294
|Title=XRCC2 R188H (rs3218536), XRCC3 T241M (rs861539) and R243H (rs77381814) Single Nucleotide Polymorphisms in Cervical Cancer Risk
}}

{{PMID Auto
|PMID=24621646
|Title=Impact of XRCC2 Arg188His Polymorphism on Cancer Susceptibility: A Meta-Analysis
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}