{{Rsnum
|rsid=3219156
|Gene=ALS2
|Chromosome=2
|position=201760892
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.101
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ALS2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 80.5 | 19.5 | 0.0
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 59.2 | 34.0 | 6.8
| ASW | 68.4 | 26.3 | 5.3
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 93.1 | 6.9 | 0.0
| LWK | 48.2 | 46.4 | 5.5
| MEX | 82.8 | 17.2 | 0.0
| MKK | 76.3 | 22.4 | 1.3
| TSI | 81.4 | 16.7 | 2.0
| HapMapRevision=28
}}{{Venter SNP
|rsid=3219156
|allele=T
|frequency=0.9
|uid=1103658338461
|type=homozygous_SNP
|hugo=ALS2
|ensembl gene=ENSG00000003393
|ensembl transcript=ENST00000264276
|sift=TOLERATED
|disease=Defects in ALS2 are the cause of infantile-onset ascending spastic paralysis (IAHSP) (MIM:607225). IAHSP is characterized by progressive spasticity and weakness of limbs.
}}

{{GET Evidence
|gene=ALS2
|aa_change=Val368Met
|aa_change_short=V368M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs3219156
|overall_frequency_n=8448
|overall_frequency_d=9838
|overall_frequency=0.858711
|n_genomes=54
|n_genomes_annotated=0
|n_haplomes=98
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=1
|qualitycomment_in_silico=Y
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=0
|autoscore=3
|n_web_uneval=5
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}